Rapid loss of activity but not serum concentration in a passive infusion clinical trial of an HIV neutralizing antibody.
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| Title: | Rapid loss of activity but not serum concentration in a passive infusion clinical trial of an HIV neutralizing antibody. |
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| Authors: | Mahomed S; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Medical Microbiology, University of Kwazulu-Natal, Durban, South Africa., Mkhize NN; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Serebryannyy LA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Hermanus T; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Kgagudi P; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Kaldine H; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Lambson B; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Narpala SR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Basappa M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Castro M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Carlton K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Sands JT; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Gall JG; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Morris L; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa., Karim QA; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA., Moore PL; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Karim SA; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA., Doria-Rose N; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2025 Sep 07. Date of Electronic Publication: 2025 Sep 07. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41018010 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Rapid loss of activity but not serum concentration in a passive infusion clinical trial of an HIV neutralizing antibody. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Mahomed+S%22">Mahomed S</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Medical Microbiology, University of Kwazulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Mkhize+NN%22">Mkhize NN</searchLink>; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa.<br /><searchLink fieldCode="AU" term="%22Serebryannyy+LA%22">Serebryannyy LA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hermanus+T%22">Hermanus T</searchLink>; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa.<br /><searchLink fieldCode="AU" term="%22Kgagudi+P%22">Kgagudi P</searchLink>; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa.<br /><searchLink fieldCode="AU" term="%22Kaldine+H%22">Kaldine H</searchLink>; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa.<br /><searchLink fieldCode="AU" term="%22Lambson+B%22">Lambson B</searchLink>; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa.<br /><searchLink fieldCode="AU" term="%22Narpala+SR%22">Narpala SR</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Basappa+M%22">Basappa M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Castro+M%22">Castro M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lin+BC%22">Lin BC</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Carlton+K%22">Carlton K</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Sands+JT%22">Sands JT</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Gall+JG%22">Gall JG</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Koup+RA%22">Koup RA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Morris+L%22">Morris L</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.<br /><searchLink fieldCode="AU" term="%22Karim+QA%22">Karim QA</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.<br /><searchLink fieldCode="AU" term="%22Moore+PL%22">Moore PL</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa.<br /><searchLink fieldCode="AU" term="%22Karim+SA%22">Karim SA</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.<br /><searchLink fieldCode="AU" term="%22Doria-Rose+N%22">Doria-Rose N</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2025 Sep 07. <i>Date of Electronic Publication: </i>2025 Sep 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41018010 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.09.04.25334949 Languages: – Code: eng Text: English Titles: – TitleFull: Rapid loss of activity but not serum concentration in a passive infusion clinical trial of an HIV neutralizing antibody. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mahomed S – PersonEntity: Name: NameFull: Mkhize NN – PersonEntity: Name: NameFull: Serebryannyy LA – PersonEntity: Name: NameFull: Hermanus T – PersonEntity: Name: NameFull: Kgagudi P – PersonEntity: Name: NameFull: Kaldine H – PersonEntity: Name: NameFull: Lambson B – PersonEntity: Name: NameFull: Narpala SR – PersonEntity: Name: NameFull: Basappa M – PersonEntity: Name: NameFull: Castro M – PersonEntity: Name: NameFull: Lin BC – PersonEntity: Name: NameFull: Carlton K – PersonEntity: Name: NameFull: Sands JT – PersonEntity: Name: NameFull: Gall JG – PersonEntity: Name: NameFull: Koup RA – PersonEntity: Name: NameFull: Morris L – PersonEntity: Name: NameFull: Karim QA – PersonEntity: Name: NameFull: Moore PL – PersonEntity: Name: NameFull: Karim SA – PersonEntity: Name: NameFull: Doria-Rose N IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 09 Text: 2025 Sep 07 Type: published Y: 2025 Titles: – TitleFull: MedRxiv : the preprint server for health sciences Type: main |
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