Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration.
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| Title: | Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration. |
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| Authors: | Povala G; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bellaver B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bastiani MA; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Ferrari-Souza JP; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Aguzzoli CS; Brain Institute of Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.; Global Brain Health Institute, University of California, San Francisco, California, USA., Leffa DT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ferreira PCL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lussier FZ; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Rocha A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Zalzale H; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Soares C; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bauer-Negrini G; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Therriault J; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Rahmouni N; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Stevenson J; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Servaes S; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Tissot C; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Zatt B; Graduate Program in Computing, Universidade Federal de Pelotas (UFPEL), Pelotas, Rio Grande do Sul, Brazil., Karikari TK; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Ikonomovic MD; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Geriatric Research Education and Clinical Center, VA Pittsburgh HS, Pittsburgh, Pennsylvania, USA., Villemagne VL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gauthier S; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Zimmer ER; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Brain Institute of Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.; Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Tudorascu DL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Biostatistics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Benedet AL; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Rosa-Neto P; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.; Brain Imaging Centre, Montreal Neurological Institute-Hospital, Montreal, Quebec, Canada.; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Pascoal TA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. |
| Source: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70746. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1552-5279 |
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| DOI: | 10.1002/alz.70746 |
