Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry.

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Title: Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry.
Authors: Cortellini A; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy alessiocortellini@gmail.com.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK., Santo V; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Brunetti L; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK., Garbo E; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Pinato DJ; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.; Translational Medicine Department, University of Eastern Piedmont, Novara, Italy., La Cava G; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Naidoo J; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland.; RCSI University of Health Sciences, Dublin, Ireland.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA., Katz A; Oncology Center, Hospital Sírio-Libanês, São Paulo, SP, Brazil., Loza M; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA., Neal JW; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA., Genova C; Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Gettinger S; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Kim SY; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Jayakrishnan R; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., El Zarif T; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Russano M; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Pecci F; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Di Federico A; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Alessi JV; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA., Montrone M; Medical Thoracic Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Owen DH; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, OSUCCC - James, The Ohio State University, Columbus, OH, USA., Ramella S; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.; Operative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Signorelli D; Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy., Fidler MJ; Division of Hematology/Oncology/Stem cell transplant, Rush University Medical Center, Chicago, IL, USA., Li M; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Camerini A; Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Italy., Halmos B; Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA., Vincenzi B; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Metro G; Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliero-Universitaria di Perugia, Perugia, Italy., Passiglia F; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy., Yendamuri S; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Guida A; SC Oncologia Medica e Traslazionale, Azienda Ospedaliera Santa Maria di Terni, Terni, Italy., Ghidini M; Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., D'Alessio A; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK., Banna GL; Department of Oncology, Portsmouth Hospitals University NHS Trust, Portsmouth, Portsmouth, UK., Fulgenzi CAM; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK., Grisanti S; Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK., Grossi F; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., D'Incecco A; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy., Josephides E; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Van Hemelrijck M; Translational Oncology and Urology Research, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Russo A; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy., Gelibter A; Department of Oncology, Careggi University Hospital, Florence, Italy., Spinelli G; Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK., Verrico M; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland., Tomasik B; Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland., Giusti R; Medical Oncology Unit, Sant'Andrea Hospital, Roma, Italy., Balachandran K; Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK., Bria E; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy., Sebastian M; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Rost M; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Forster M; The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK., Mukherjee U; The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK., Landi L; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy., Mazzoni F; Department of Oncology, Careggi University Hospital, Florence, Italy., Aujayeb A; Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK., Dupont M; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland., Curioni-Fontecedro A; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland., Chiari R; UOC Oncologia, AST Pesaro Urbino, Pesaro, Italy., Sforza V; Thoracic Medical Oncology, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', Naples, Italy., Tiseo M; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Medical Oncology Unit, University Hospital of Parma, Parma, Italy., Friedlaender A; Clinique Générale Beaulieu, Geneva, Switzerland., Addeo A; Oncology Service, University Hospital of Geneva, Geneva, Switzerland., Zoratto F; Medical Oncology, Ospedale Santa Maria Goretti, Latina, Lazio, Italy., De Tursi M; Department of Innovative Technologies in Medicine & Dentistry, University G. D'Annunzio, Chieti-Pescara, Chieti, Italy., Cantini L; Fortrea Inc, Durham, North Carolina, USA., Roca E; Oncologia Toracica - Lung Unit, Ospedale P. Pederzoli, Peschiera del Garda, Italy., Mountzios G; 4th Department of Medical Oncology and Clinical Trials Unit, Henry Dunant Hospital Center, Athens, Greece., Rocco D; Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy., Della Gravara L; Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy., Kalvapudi S; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Inno A; Medical Oncology Unit, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy., Bironzo P; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy., Di Marco Barros R; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., O'Reilly D; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland., Fitzpatrick O; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland., Karapanagiotou E; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Monnet I; Service de Pneumologie, Centre Hospitalier Intercommunal, Creteil, France., Baena J; Hospital Universitario 12 de Octubre, Madrid, Spain., Macerelli M; Department of Oncology, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy., Piedra A; Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain., Agustoni F; Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Cortinovis DL; Division of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori di Monza, Monza, Italy.; Department of Clinical Medicine, University of Milano-Bicocca, Milano, Italy., Tonini G; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Minuti G; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy., Bennati C; Oncology Unit, Santa Maria delle Croci Hospital Ravenna, AUSL della Romagna, Ravenna, Italy., Mezquita L; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain., Gorría T; Department of Medical Oncology, Hospital Clinic, Barcelona, Spain., Servetto A; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Beninato T; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Lo Russo G; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Prelaj A; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milan, Italy., De Giglio A; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Rogado J; Medical Oncology Department, Hospital Universitario Infanta Leonor, Madrid, Spain., Moliner L; Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain., Nadal E; Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain., Biello F; Translational Medicine Department, University of Eastern Piedmont, Novara, Italy., Nana FA; Division of Pneumology, Cliniques Universitaires St-Luc, UCLouvain, Brussels, Belgium., Dingemans AM; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands., Aerts JGJV; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands., Ferrara R; Università Vita-Salute San Raffaele, Milano, Italy.; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy., Abu Hejleh T; Department of Internal Medicine, Medical Oncology, King Hussein Cancer Center, Amman, Jordan.; Department of Internal Medicine, Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA, USA., Takada K; Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan., Naqash AR; Medical Oncology/TSET Phase 1 Program, The University of Oklahoma Stephenson Cancer Center, Oklahoma City, Oklahoma, USA., Garassino MC; Thoracic Oncology Program, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA., Peters S; Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland., Wakelee HA; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA., Nassar AH; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Soda P; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.; Department of Diagnostics and Intervention, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden., Caruso CM; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy., Guarrasi V; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Sep 29; Vol. 13 (9). Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-1426
DOI:10.1136/jitc-2025-012423