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Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry.

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Title: Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry.
Authors: Cortellini A; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy alessiocortellini@gmail.com.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK., Santo V; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Brunetti L; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK., Garbo E; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Pinato DJ; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.; Translational Medicine Department, University of Eastern Piedmont, Novara, Italy., La Cava G; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Naidoo J; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland.; RCSI University of Health Sciences, Dublin, Ireland.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA., Katz A; Oncology Center, Hospital Sírio-Libanês, São Paulo, SP, Brazil., Loza M; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA., Neal JW; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA., Genova C; Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Gettinger S; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Kim SY; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Jayakrishnan R; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., El Zarif T; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Russano M; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Pecci F; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Di Federico A; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Alessi JV; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA., Montrone M; Medical Thoracic Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Owen DH; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, OSUCCC - James, The Ohio State University, Columbus, OH, USA., Ramella S; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.; Operative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Signorelli D; Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy., Fidler MJ; Division of Hematology/Oncology/Stem cell transplant, Rush University Medical Center, Chicago, IL, USA., Li M; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Camerini A; Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Italy., Halmos B; Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA., Vincenzi B; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Metro G; Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliero-Universitaria di Perugia, Perugia, Italy., Passiglia F; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy., Yendamuri S; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Guida A; SC Oncologia Medica e Traslazionale, Azienda Ospedaliera Santa Maria di Terni, Terni, Italy., Ghidini M; Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., D'Alessio A; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK., Banna GL; Department of Oncology, Portsmouth Hospitals University NHS Trust, Portsmouth, Portsmouth, UK., Fulgenzi CAM; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK., Grisanti S; Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK., Grossi F; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., D'Incecco A; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy., Josephides E; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Van Hemelrijck M; Translational Oncology and Urology Research, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Russo A; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy., Gelibter A; Department of Oncology, Careggi University Hospital, Florence, Italy., Spinelli G; Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK., Verrico M; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland., Tomasik B; Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland., Giusti R; Medical Oncology Unit, Sant'Andrea Hospital, Roma, Italy., Balachandran K; Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK., Bria E; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy., Sebastian M; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Rost M; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Forster M; The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK., Mukherjee U; The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK., Landi L; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy., Mazzoni F; Department of Oncology, Careggi University Hospital, Florence, Italy., Aujayeb A; Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK., Dupont M; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland., Curioni-Fontecedro A; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland., Chiari R; UOC Oncologia, AST Pesaro Urbino, Pesaro, Italy., Sforza V; Thoracic Medical Oncology, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', Naples, Italy., Tiseo M; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Medical Oncology Unit, University Hospital of Parma, Parma, Italy., Friedlaender A; Clinique Générale Beaulieu, Geneva, Switzerland., Addeo A; Oncology Service, University Hospital of Geneva, Geneva, Switzerland., Zoratto F; Medical Oncology, Ospedale Santa Maria Goretti, Latina, Lazio, Italy., De Tursi M; Department of Innovative Technologies in Medicine & Dentistry, University G. D'Annunzio, Chieti-Pescara, Chieti, Italy., Cantini L; Fortrea Inc, Durham, North Carolina, USA., Roca E; Oncologia Toracica - Lung Unit, Ospedale P. Pederzoli, Peschiera del Garda, Italy., Mountzios G; 4th Department of Medical Oncology and Clinical Trials Unit, Henry Dunant Hospital Center, Athens, Greece., Rocco D; Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy., Della Gravara L; Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy., Kalvapudi S; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Inno A; Medical Oncology Unit, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy., Bironzo P; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy., Di Marco Barros R; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., O'Reilly D; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland., Fitzpatrick O; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland., Karapanagiotou E; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Monnet I; Service de Pneumologie, Centre Hospitalier Intercommunal, Creteil, France., Baena J; Hospital Universitario 12 de Octubre, Madrid, Spain., Macerelli M; Department of Oncology, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy., Piedra A; Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain., Agustoni F; Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Cortinovis DL; Division of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori di Monza, Monza, Italy.; Department of Clinical Medicine, University of Milano-Bicocca, Milano, Italy., Tonini G; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Minuti G; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy., Bennati C; Oncology Unit, Santa Maria delle Croci Hospital Ravenna, AUSL della Romagna, Ravenna, Italy., Mezquita L; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain., Gorría T; Department of Medical Oncology, Hospital Clinic, Barcelona, Spain., Servetto A; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Beninato T; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Lo Russo G; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Prelaj A; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milan, Italy., De Giglio A; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Rogado J; Medical Oncology Department, Hospital Universitario Infanta Leonor, Madrid, Spain., Moliner L; Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain., Nadal E; Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain., Biello F; Translational Medicine Department, University of Eastern Piedmont, Novara, Italy., Nana FA; Division of Pneumology, Cliniques Universitaires St-Luc, UCLouvain, Brussels, Belgium., Dingemans AM; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands., Aerts JGJV; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands., Ferrara R; Università Vita-Salute San Raffaele, Milano, Italy.; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy., Abu Hejleh T; Department of Internal Medicine, Medical Oncology, King Hussein Cancer Center, Amman, Jordan.; Department of Internal Medicine, Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA, USA., Takada K; Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan., Naqash AR; Medical Oncology/TSET Phase 1 Program, The University of Oklahoma Stephenson Cancer Center, Oklahoma City, Oklahoma, USA., Garassino MC; Thoracic Oncology Program, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA., Peters S; Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland., Wakelee HA; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA., Nassar AH; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Soda P; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.; Department of Diagnostics and Intervention, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden., Caruso CM; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy., Guarrasi V; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Sep 29; Vol. 13 (9). Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41022528
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Cortellini+A%22">Cortellini A</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy alessiocortellini@gmail.com.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Santo+V%22">Santo V</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brunetti+L%22">Brunetti L</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Garbo+E%22">Garbo E</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pinato+DJ%22">Pinato DJ</searchLink>; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.; Translational Medicine Department, University of Eastern Piedmont, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22La+Cava+G%22">La Cava G</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Naidoo+J%22">Naidoo J</searchLink>; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland.; RCSI University of Health Sciences, Dublin, Ireland.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Katz+A%22">Katz A</searchLink>; Oncology Center, Hospital Sírio-Libanês, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Loza+M%22">Loza M</searchLink>; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Neal+JW%22">Neal JW</searchLink>; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Genova+C%22">Genova C</searchLink>; Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Gettinger+S%22">Gettinger S</searchLink>; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kim+SY%22">Kim SY</searchLink>; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Jayakrishnan+R%22">Jayakrishnan R</searchLink>; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22El+Zarif+T%22">El Zarif T</searchLink>; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Russano+M%22">Russano M</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pecci+F%22">Pecci F</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Di+Federico+A%22">Di Federico A</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alessi+JV%22">Alessi JV</searchLink>; Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Montrone+M%22">Montrone M</searchLink>; Medical Thoracic Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Owen+DH%22">Owen DH</searchLink>; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, OSUCCC - James, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ramella+S%22">Ramella S</searchLink>; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.; Operative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Signorelli+D%22">Signorelli D</searchLink>; Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Fidler+MJ%22">Fidler MJ</searchLink>; Division of Hematology/Oncology/Stem cell transplant, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Camerini+A%22">Camerini A</searchLink>; Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Italy.<br /><searchLink fieldCode="AU" term="%22Halmos+B%22">Halmos B</searchLink>; Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vincenzi+B%22">Vincenzi B</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Metro+G%22">Metro G</searchLink>; Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliero-Universitaria di Perugia, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Passiglia+F%22">Passiglia F</searchLink>; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Yendamuri+S%22">Yendamuri S</searchLink>; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Guida+A%22">Guida A</searchLink>; SC Oncologia Medica e Traslazionale, Azienda Ospedaliera Santa Maria di Terni, Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Ghidini+M%22">Ghidini M</searchLink>; Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22D'Alessio+A%22">D'Alessio A</searchLink>; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Banna+GL%22">Banna GL</searchLink>; Department of Oncology, Portsmouth Hospitals University NHS Trust, Portsmouth, Portsmouth, UK.<br /><searchLink fieldCode="AU" term="%22Fulgenzi+CAM%22">Fulgenzi CAM</searchLink>; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Grisanti+S%22">Grisanti S</searchLink>; Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Grossi+F%22">Grossi F</searchLink>; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22D'Incecco+A%22">D'Incecco A</searchLink>; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Josephides+E%22">Josephides E</searchLink>; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Van+Hemelrijck+M%22">Van Hemelrijck M</searchLink>; Translational Oncology and Urology Research, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Russo+A%22">Russo A</searchLink>; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gelibter+A%22">Gelibter A</searchLink>; Department of Oncology, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Spinelli+G%22">Spinelli G</searchLink>; Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK.<br /><searchLink fieldCode="AU" term="%22Verrico+M%22">Verrico M</searchLink>; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tomasik+B%22">Tomasik B</searchLink>; Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.<br /><searchLink fieldCode="AU" term="%22Giusti+R%22">Giusti R</searchLink>; Medical Oncology Unit, Sant'Andrea Hospital, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Balachandran+K%22">Balachandran K</searchLink>; Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Bria+E%22">Bria E</searchLink>; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Sebastian+M%22">Sebastian M</searchLink>; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Rost+M%22">Rost M</searchLink>; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Forster+M%22">Forster M</searchLink>; The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Mukherjee+U%22">Mukherjee U</searchLink>; The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Landi+L%22">Landi L</searchLink>; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzoni+F%22">Mazzoni F</searchLink>; Department of Oncology, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Aujayeb+A%22">Aujayeb A</searchLink>; Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK.<br /><searchLink fieldCode="AU" term="%22Dupont+M%22">Dupont M</searchLink>; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.<br /><searchLink fieldCode="AU" term="%22Curioni-Fontecedro+A%22">Curioni-Fontecedro A</searchLink>; Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chiari+R%22">Chiari R</searchLink>; UOC Oncologia, AST Pesaro Urbino, Pesaro, Italy.<br /><searchLink fieldCode="AU" term="%22Sforza+V%22">Sforza V</searchLink>; Thoracic Medical Oncology, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Tiseo+M%22">Tiseo M</searchLink>; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Friedlaender+A%22">Friedlaender A</searchLink>; Clinique Générale Beaulieu, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Addeo+A%22">Addeo A</searchLink>; Oncology Service, University Hospital of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zoratto+F%22">Zoratto F</searchLink>; Medical Oncology, Ospedale Santa Maria Goretti, Latina, Lazio, Italy.<br /><searchLink fieldCode="AU" term="%22De+Tursi+M%22">De Tursi M</searchLink>; Department of Innovative Technologies in Medicine & Dentistry, University G. D'Annunzio, Chieti-Pescara, Chieti, Italy.<br /><searchLink fieldCode="AU" term="%22Cantini+L%22">Cantini L</searchLink>; Fortrea Inc, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Roca+E%22">Roca E</searchLink>; Oncologia Toracica - Lung Unit, Ospedale P. Pederzoli, Peschiera del Garda, Italy.<br /><searchLink fieldCode="AU" term="%22Mountzios+G%22">Mountzios G</searchLink>; 4th Department of Medical Oncology and Clinical Trials Unit, Henry Dunant Hospital Center, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Rocco+D%22">Rocco D</searchLink>; Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Della+Gravara+L%22">Della Gravara L</searchLink>; Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Kalvapudi+S%22">Kalvapudi S</searchLink>; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Inno+A%22">Inno A</searchLink>; Medical Oncology Unit, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy.<br /><searchLink fieldCode="AU" term="%22Bironzo+P%22">Bironzo P</searchLink>; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Marco+Barros+R%22">Di Marco Barros R</searchLink>; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22O'Reilly+D%22">O'Reilly D</searchLink>; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Fitzpatrick+O%22">Fitzpatrick O</searchLink>; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Karapanagiotou+E%22">Karapanagiotou E</searchLink>; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Monnet+I%22">Monnet I</searchLink>; Service de Pneumologie, Centre Hospitalier Intercommunal, Creteil, France.<br /><searchLink fieldCode="AU" term="%22Baena+J%22">Baena J</searchLink>; Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Macerelli+M%22">Macerelli M</searchLink>; Department of Oncology, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Piedra+A%22">Piedra A</searchLink>; Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Agustoni+F%22">Agustoni F</searchLink>; Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Cortinovis+DL%22">Cortinovis DL</searchLink>; Division of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori di Monza, Monza, Italy.; Department of Clinical Medicine, University of Milano-Bicocca, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Tonini+G%22">Tonini G</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Minuti+G%22">Minuti G</searchLink>; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bennati+C%22">Bennati C</searchLink>; Oncology Unit, Santa Maria delle Croci Hospital Ravenna, AUSL della Romagna, Ravenna, Italy.<br /><searchLink fieldCode="AU" term="%22Mezquita+L%22">Mezquita L</searchLink>; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gorría+T%22">Gorría T</searchLink>; Department of Medical Oncology, Hospital Clinic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Servetto+A%22">Servetto A</searchLink>; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Beninato+T%22">Beninato T</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Lo+Russo+G%22">Lo Russo G</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Prelaj+A%22">Prelaj A</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Giglio+A%22">De Giglio A</searchLink>; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Rogado+J%22">Rogado J</searchLink>; Medical Oncology Department, Hospital Universitario Infanta Leonor, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Moliner+L%22">Moliner L</searchLink>; Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Nadal+E%22">Nadal E</searchLink>; Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Biello+F%22">Biello F</searchLink>; Translational Medicine Department, University of Eastern Piedmont, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Nana+FA%22">Nana FA</searchLink>; Division of Pneumology, Cliniques Universitaires St-Luc, UCLouvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Dingemans+AM%22">Dingemans AM</searchLink>; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Aerts+JGJV%22">Aerts JGJV</searchLink>; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Ferrara+R%22">Ferrara R</searchLink>; Università Vita-Salute San Raffaele, Milano, Italy.; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Abu+Hejleh+T%22">Abu Hejleh T</searchLink>; Department of Internal Medicine, Medical Oncology, King Hussein Cancer Center, Amman, Jordan.; Department of Internal Medicine, Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Takada+K%22">Takada K</searchLink>; Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Naqash+AR%22">Naqash AR</searchLink>; Medical Oncology/TSET Phase 1 Program, The University of Oklahoma Stephenson Cancer Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Garassino+MC%22">Garassino MC</searchLink>; Thoracic Oncology Program, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Peters+S%22">Peters S</searchLink>; Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wakelee+HA%22">Wakelee HA</searchLink>; Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nassar+AH%22">Nassar AH</searchLink>; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Ricciuti+B%22">Ricciuti B</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Soda+P%22">Soda P</searchLink>; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.; Department of Diagnostics and Intervention, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Caruso+CM%22">Caruso CM</searchLink>; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Guarrasi+V%22">Guarrasi V</searchLink>; Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2025 Sep 29; Vol. 13 (9). <i>Date of Electronic Publication: </i>2025 Sep 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2025-012423
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      – TitleFull: Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry.
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            NameFull: Garassino MC
      – PersonEntity:
          Name:
            NameFull: Peters S
      – PersonEntity:
          Name:
            NameFull: Wakelee HA
      – PersonEntity:
          Name:
            NameFull: Nassar AH
      – PersonEntity:
          Name:
            NameFull: Ricciuti B
      – PersonEntity:
          Name:
            NameFull: Soda P
      – PersonEntity:
          Name:
            NameFull: Caruso CM
      – PersonEntity:
          Name:
            NameFull: Guarrasi V
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 29
              M: 09
              Text: 2025 Sep 29
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2051-1426
          Numbering:
            – Type: volume
              Value: 13
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Journal for immunotherapy of cancer
              Type: main
ResultId 1