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Assessment of brain penetration and tumor accumulation of niraparib and olaparib: insights from multimodal imaging in preclinical models.

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Title: Assessment of brain penetration and tumor accumulation of niraparib and olaparib: insights from multimodal imaging in preclinical models.
Authors: Groseclose MR; Bioimaging, GSK, Collegeville, PA, USA. reid.x.groseclose@gsk.com., Barry JA; Bioimaging, GSK, Collegeville, PA, USA., Skedzielewski T; Bioimaging, GSK, Collegeville, PA, USA., Pang Y; DMPK, GSK, Collegeville, PA, USA., Li Y; DMPK, GSK, Collegeville, PA, USA., McDermott G; Laboratory Animal Sciences and Governance, GSK, Collegeville, PA, USA., Deutsch J; Laboratory Animal Sciences and Governance, GSK, Collegeville, PA, USA., Balabhadrapatruni C; Oncology Research Unit, GSK, Collegeville, PA, USA., Benson W; Bioimaging, GSK, Collegeville, PA, USA., Lim D; Research Statistics, Biostatistics, GSK, Collegeville, PA, USA., Tran H; Research Statistics, Biostatistics, GSK, Collegeville, PA, USA., Minthorn E; DMPK, GSK, Collegeville, PA, USA., Kmett C; DMPK, GSK, Collegeville, PA, USA., Roethke T; DMPK, GSK, Collegeville, PA, USA., Berry S; DMPK, GSK, Collegeville, PA, USA., McCormick E; DMPK, GSK, Collegeville, PA, USA., Feeney W; Laboratory Animal Sciences and Governance, GSK, Collegeville, PA, USA., Ringenberg MA; Nonclinical Safety, GSK, Collegeville, PA, USA., Maguire S; Laboratory Animal Sciences and Governance, GSK, Collegeville, PA, USA., Sharma G; Oncology Research Unit, GSK, Collegeville, PA, USA., Aziez A; Global Medical Affairs Oncology, GSK, Zug, Switzerland., Paul EM; Oncology Medicine Development, GSK, Collegeville, PA, USA., Taskar K; DMPK, GSK, Collegeville, PA, USA., Gada K; DMPK, GSK, Collegeville, PA, USA., Alsaid H; Bioimaging, GSK, Collegeville, PA, USA.
Source: Scientific reports [Sci Rep] 2025 Sep 29; Vol. 15 (1), pp. 33670. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2025 Sep 29; Vol. 15 (1), pp. 33670. <i>Date of Electronic Publication: </i>2025 Sep 29.
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