Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.

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Title: Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.
Authors: Mellor KM; Department of Physiology, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Varma U; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Koutsifeli P; Department of Physiology, University of Auckland, Auckland, New Zealand., Curl CL; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Janssens JV; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Daniels LJ; Department of Physiology, University of Auckland, Auckland, New Zealand., Bernasochi GB; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Raaijmakers AJA; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Annandale M; Department of Physiology, University of Auckland, Auckland, New Zealand., Li X; Department of Physiology, University of Auckland, Auckland, New Zealand., James SL; Department of Physiology, University of Auckland, Auckland, New Zealand., Taylor DJ; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Raedschelders K; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Weeks KL; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia., Mills RJ; Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Parton RG; Centre for Microscopy and Microanalysis and Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Hu X; Institute of Molecular Medicine, Peking University, Beijing, China., Bell JR; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, Victoria, Australia., O'Brien TJ; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.; Department of Neuroscience, Monash University, Melbourne, Victoria, Australia., Katare R; Department of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand., Porrello ER; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Hudson JE; School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Xiao RP; Institute of Molecular Medicine, Peking University, Beijing, China., Van Eyk JE; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gottlieb RA; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Delbridge LMD; Department of Physiology, University of Auckland, Auckland, New Zealand. lmd@unimelb.edu.au.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia. lmd@unimelb.edu.au.
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2025 Nov; Vol. 4 (11), pp. 1487-1500. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2731-0590
DOI:10.1038/s44161-025-00726-x