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Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.

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Title: Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.
Authors: Mellor KM; Department of Physiology, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Varma U; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Koutsifeli P; Department of Physiology, University of Auckland, Auckland, New Zealand., Curl CL; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Janssens JV; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Daniels LJ; Department of Physiology, University of Auckland, Auckland, New Zealand., Bernasochi GB; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Raaijmakers AJA; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Annandale M; Department of Physiology, University of Auckland, Auckland, New Zealand., Li X; Department of Physiology, University of Auckland, Auckland, New Zealand., James SL; Department of Physiology, University of Auckland, Auckland, New Zealand., Taylor DJ; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Raedschelders K; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Weeks KL; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia., Mills RJ; Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Parton RG; Centre for Microscopy and Microanalysis and Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Hu X; Institute of Molecular Medicine, Peking University, Beijing, China., Bell JR; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, Victoria, Australia., O'Brien TJ; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.; Department of Neuroscience, Monash University, Melbourne, Victoria, Australia., Katare R; Department of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand., Porrello ER; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Hudson JE; School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Xiao RP; Institute of Molecular Medicine, Peking University, Beijing, China., Van Eyk JE; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gottlieb RA; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Delbridge LMD; Department of Physiology, University of Auckland, Auckland, New Zealand. lmd@unimelb.edu.au.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia. lmd@unimelb.edu.au.
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2025 Nov; Vol. 4 (11), pp. 1487-1500. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
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  Data: Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.
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  Data: <searchLink fieldCode="AU" term="%22Mellor+KM%22">Mellor KM</searchLink>; Department of Physiology, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Varma+U%22">Varma U</searchLink>; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Koutsifeli+P%22">Koutsifeli P</searchLink>; Department of Physiology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Curl+CL%22">Curl CL</searchLink>; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Janssens+JV%22">Janssens JV</searchLink>; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Daniels+LJ%22">Daniels LJ</searchLink>; Department of Physiology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Bernasochi+GB%22">Bernasochi GB</searchLink>; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Raaijmakers+AJA%22">Raaijmakers AJA</searchLink>; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Annandale+M%22">Annandale M</searchLink>; Department of Physiology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Physiology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22James+SL%22">James SL</searchLink>; Department of Physiology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Taylor+DJ%22">Taylor DJ</searchLink>; Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Raedschelders+K%22">Raedschelders K</searchLink>; Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Weeks+KL%22">Weeks KL</searchLink>; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Mills+RJ%22">Mills RJ</searchLink>; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Parton+RG%22">Parton RG</searchLink>; Centre for Microscopy and Microanalysis and Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Institute of Molecular Medicine, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Bell+JR%22">Bell JR</searchLink>; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22O'Brien+TJ%22">O'Brien TJ</searchLink>; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.; Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Katare+R%22">Katare R</searchLink>; Department of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Porrello+ER%22">Porrello ER</searchLink>; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hudson+JE%22">Hudson JE</searchLink>; School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Xiao+RP%22">Xiao RP</searchLink>; Institute of Molecular Medicine, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Van+Eyk+JE%22">Van Eyk JE</searchLink>; Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gottlieb+RA%22">Gottlieb RA</searchLink>; Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Delbridge+LMD%22">Delbridge LMD</searchLink>; Department of Physiology, University of Auckland, Auckland, New Zealand. lmd@unimelb.edu.au.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia. lmd@unimelb.edu.au.
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  Data: <searchLink fieldCode="JN" term="%229918284280206676%22">Nature cardiovascular research</searchLink> [Nat Cardiovasc Res] 2025 Nov; Vol. 4 (11), pp. 1487-1500. <i>Date of Electronic Publication: </i>2025 Sep 29.
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