IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers.

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Bibliographic Details
Title: IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers.
Authors: Zhang X; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA., Xiao Q; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.; Institute of Modern Biology, Nanjing University, Nanjing, China., Zeng L; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA., Hashmi F; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.; Yale College, New Haven, CT, USA., Sato K; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA., Hartwich TMP; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA., Mansolf M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA., Yang-Hartwich Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA., Su X; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Cancer Center, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Center for Immuno-Oncology, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Center for systems and Engineering Immunology, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Stem Cell Center, New Haven, CT, USA. Xiaolei.su@yale.edu.
Source: Nature chemical biology [Nat Chem Biol] 2026 Mar; Vol. 22 (3), pp. 379-391. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1552-4469
DOI:10.1038/s41589-025-02031-x