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IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers.

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Title: IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers.
Authors: Zhang X; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA., Xiao Q; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.; Institute of Modern Biology, Nanjing University, Nanjing, China., Zeng L; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA., Hashmi F; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.; Yale College, New Haven, CT, USA., Sato K; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA., Hartwich TMP; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA., Mansolf M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA., Yang-Hartwich Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA., Su X; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Cancer Center, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Center for Immuno-Oncology, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Center for systems and Engineering Immunology, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Stem Cell Center, New Haven, CT, USA. Xiaolei.su@yale.edu.
Source: Nature chemical biology [Nat Chem Biol] 2026 Mar; Vol. 22 (3), pp. 379-391. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+Q%22">Xiao Q</searchLink>; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.; Institute of Modern Biology, Nanjing University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zeng+L%22">Zeng L</searchLink>; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hashmi+F%22">Hashmi F</searchLink>; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.; Yale College, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Sato+K%22">Sato K</searchLink>; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hartwich+TMP%22">Hartwich TMP</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Mansolf+M%22">Mansolf M</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Yang-Hartwich+Y%22">Yang-Hartwich Y</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Su+X%22">Su X</searchLink>; Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Cancer Center, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Center for Immuno-Oncology, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Center for systems and Engineering Immunology, New Haven, CT, USA. Xiaolei.su@yale.edu.; Yale Stem Cell Center, New Haven, CT, USA. Xiaolei.su@yale.edu.
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  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2026 Mar; Vol. 22 (3), pp. 379-391. <i>Date of Electronic Publication: </i>2025 Sep 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231976 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-4469 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215524450%22">15524450 </searchLink><i>NLM ISO Abbreviation: </i>Nat Chem Biol <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar
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