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Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis.

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Title: Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis.
Authors: Liesenfeld O; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA. oliver.liesenfeld@gmail.com.; Institute of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany. oliver.liesenfeld@gmail.com., Arora S; Department of Emergency Medicine, University of Southern California, Los Angeles, CA, USA., Aufderheide TP; Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Clements CM; Department of Emergency Medicine, Mayo Clinic, Rochester, MN, USA., DeVos E; Department of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA., Fischer M; Department of Emergency Medicine, Georgetown University School of Medicine, Medstar Washington Hospital Center, Washington, DC, USA., Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Athens, Greece., House S; Department of Emergency Medicine, Washington University, St. Louis, MO, USA., Humphries RL; Department of Emergency Medicine, University of Kentucky, Lexington, KY, USA., Gill JK; Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA., Liu E; Department of Emergency Medicine, Hackensack Meridian Health, Jersey Shore University Medical Center HOPE Tower, Neptune, NJ, USA., Mace SE; Department of Emergency Medicine, Cleveland Clinic, Cleveland, OH, USA., May L; Department of Emergency Medicine, University of California, Davis, Davis, CA, USA., Michelson E; Department of Emergency Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA., Osborn TM; Department of Emergency Medicine, Washington University, St. Louis, MO, USA., Panacek E; University of South Alabama, Mobile, AL, USA., Rothman RE; Department of Emergency Medicine, Johns Hopkins University, Baltimore, MD, USA., Self WH; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Smithline HA; University of Massachusetts Chan Medical School-Baystate, Springfield, MA, USA., Steingrub J; University of Massachusetts Chan Medical School-Baystate, Springfield, MA, USA., Van Heukelom P; Department of Emergency Medicine, University of Iowa, Iowa City, IA, USA., Weissman A; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wilson M; Department of Emergency Medicine, Georgetown University School of Medicine, Medstar Washington Hospital Center, Washington, DC, USA., Wolk DM; Geisinger Diagnostic Medicine Institute, Geisinger Commonwealth School of Medicine, Danville, PA, USA., Wright DW; Department of Emergency Medicine, Emory University School of Medicine, Grady Memorial Hospital, Atlanta, GA, USA., Buturovic L; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA., Hasin-Brumshtein Y; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA., Damaraju N; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA., Lu C; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA., Shak JR; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA., Whitfield NN; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA., Khatri P; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA., Sweeney TE; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA., Shapiro NI; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Source: Nature medicine [Nat Med] 2025 Dec; Vol. 31 (12), pp. 4044-4054. Date of Electronic Publication: 2025 Sep 30.
Publication Type: Journal Article; Observational Study; Validation Study; Validation Study
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Liesenfeld+O%22">Liesenfeld O</searchLink>; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA. oliver.liesenfeld@gmail.com.; Institute of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany. oliver.liesenfeld@gmail.com.<br /><searchLink fieldCode="AU" term="%22Arora+S%22">Arora S</searchLink>; Department of Emergency Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Aufderheide+TP%22">Aufderheide TP</searchLink>; Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Clements+CM%22">Clements CM</searchLink>; Department of Emergency Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22DeVos+E%22">DeVos E</searchLink>; Department of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+M%22">Fischer M</searchLink>; Department of Emergency Medicine, Georgetown University School of Medicine, Medstar Washington Hospital Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Giamarellos-Bourboulis+EJ%22">Giamarellos-Bourboulis EJ</searchLink>; 4th Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22House+S%22">House S</searchLink>; Department of Emergency Medicine, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Humphries+RL%22">Humphries RL</searchLink>; Department of Emergency Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Gill+JK%22">Gill JK</searchLink>; Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Liu+E%22">Liu E</searchLink>; Department of Emergency Medicine, Hackensack Meridian Health, Jersey Shore University Medical Center HOPE Tower, Neptune, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Mace+SE%22">Mace SE</searchLink>; 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University of Massachusetts Chan Medical School-Baystate, Springfield, MA, USA.<br /><searchLink fieldCode="AU" term="%22Steingrub+J%22">Steingrub J</searchLink>; University of Massachusetts Chan Medical School-Baystate, Springfield, MA, USA.<br /><searchLink fieldCode="AU" term="%22Van+Heukelom+P%22">Van Heukelom P</searchLink>; Department of Emergency Medicine, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Weissman+A%22">Weissman A</searchLink>; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+M%22">Wilson M</searchLink>; Department of Emergency Medicine, Georgetown University School of Medicine, Medstar Washington Hospital Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Wolk+DM%22">Wolk DM</searchLink>; Geisinger Diagnostic Medicine Institute, Geisinger Commonwealth School of Medicine, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wright+DW%22">Wright DW</searchLink>; Department of Emergency Medicine, Emory University School of Medicine, Grady Memorial Hospital, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Buturovic+L%22">Buturovic L</searchLink>; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hasin-Brumshtein+Y%22">Hasin-Brumshtein Y</searchLink>; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Damaraju+N%22">Damaraju N</searchLink>; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+C%22">Lu C</searchLink>; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shak+JR%22">Shak JR</searchLink>; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Whitfield+NN%22">Whitfield NN</searchLink>; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Khatri+P%22">Khatri P</searchLink>; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sweeney+TE%22">Sweeney TE</searchLink>; Clinical Affairs, Inflammatix, Inc., Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+NI%22">Shapiro NI</searchLink>; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2025 Dec; Vol. 31 (12), pp. 4044-4054. <i>Date of Electronic Publication: </i>2025 Sep 30.
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