An active allosteric mechanism in ASAP1-mediated Arf1 GTP hydrolysis redefines PH domain function.
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| Title: | An active allosteric mechanism in ASAP1-mediated Arf1 GTP hydrolysis redefines PH domain function. |
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| Authors: | Soubias O; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Foley SL; Department of Biophysics, The Johns Hopkins University, Baltimore, MD, USA., Jian X; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Jackson RA; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Zhang Y; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.; Ring Therapeutics, Inc., Cambridge, MA, USA., Rosenberg EM Jr; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Hu BJ; Unit of Membrane Chemical Physics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Li J; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Heinrich F; Department of Physics Carnegie Mellon University, Pittsburgh, PA, USA.; NIST Center for Neutron Research, Gaithersburg, MD, USA., Johnson ME; Department of Biophysics, The Johns Hopkins University, Baltimore, MD, USA., Sodt AJ; Unit of Membrane Chemical Physics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Randazzo PA; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. randazzp@mail.nih.gov., Byrd RA; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. byrdra@nih.gov. |
| Source: | Nature communications [Nat Commun] 2025 Sep 30; Vol. 16 (1), pp. 8701. Date of Electronic Publication: 2025 Sep 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-63764-w |
