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A histone-centric multi-omics study shows that increased H3K4 methylation sustains triple-negative breast cancer phenotypes.

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Title: A histone-centric multi-omics study shows that increased H3K4 methylation sustains triple-negative breast cancer phenotypes.
Authors: Noberini R; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy. roberta.noberini@ieo.it., Robusti G; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy., Vai A; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy., Savoia EO; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy., Jodice MG; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy., Bertalot G; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.; Unità Operativa Multizonale di Anatomia Patologica, APSS, Trento, Italy.; Centre for Medical Sciences - CISMed, University of Trento, Trento, Italy., Çat B; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy., Pallavicini I; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy., Bonizzi G; Biobank for Translational and Digital Medicine, IEO European Institute of Oncology IRCCS, Milan, Italy., Capra M; Biobank for Translational and Digital Medicine, IEO European Institute of Oncology IRCCS, Milan, Italy., Sangalli CA; Clinical Trial Office, IEO European Institute of Oncology IRCSS, Milan, Italy., Zambelli F; Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy., Fusco N; Biobank for Translational and Digital Medicine, IEO European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy., Pece S; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy., Pavesi G; Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy., Minucci S; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy., Bonaldi T; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy. tiziana.bonaldi@ieo.it.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy. tiziana.bonaldi@ieo.it.
Source: Nature communications [Nat Commun] 2025 Sep 30; Vol. 16 (1), pp. 8716. Date of Electronic Publication: 2025 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A histone-centric multi-omics study shows that increased H3K4 methylation sustains triple-negative breast cancer phenotypes.
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  Data: <searchLink fieldCode="AU" term="%22Noberini+R%22">Noberini R</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy. roberta.noberini@ieo.it.<br /><searchLink fieldCode="AU" term="%22Robusti+G%22">Robusti G</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Vai+A%22">Vai A</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Savoia+EO%22">Savoia EO</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Jodice+MG%22">Jodice MG</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bertalot+G%22">Bertalot G</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.; Unità Operativa Multizonale di Anatomia Patologica, APSS, Trento, Italy.; Centre for Medical Sciences - CISMed, University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Çat+B%22">Çat B</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pallavicini+I%22">Pallavicini I</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonizzi+G%22">Bonizzi G</searchLink>; Biobank for Translational and Digital Medicine, IEO European Institute of Oncology IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Capra+M%22">Capra M</searchLink>; Biobank for Translational and Digital Medicine, IEO European Institute of Oncology IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sangalli+CA%22">Sangalli CA</searchLink>; Clinical Trial Office, IEO European Institute of Oncology IRCSS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zambelli+F%22">Zambelli F</searchLink>; Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fusco+N%22">Fusco N</searchLink>; Biobank for Translational and Digital Medicine, IEO European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pece+S%22">Pece S</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pavesi+G%22">Pavesi G</searchLink>; Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Minucci+S%22">Minucci S</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonaldi+T%22">Bonaldi T</searchLink>; Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy. tiziana.bonaldi@ieo.it.; Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy. tiziana.bonaldi@ieo.it.
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