Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia.

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Title: Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia.
Authors: Chu SQ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Chen YJ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Yang RR; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China., Teng D; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhou GZ; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China., Zhang YY; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China., Niu BY; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Xu JH; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China., Lin KX; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Yang XY; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Li XT; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. lixutong@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. lixutong@simm.ac.cn., Zheng MY; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. myzheng@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. myzheng@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. myzheng@simm.ac.cn.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. myzheng@simm.ac.cn.; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China. myzheng@simm.ac.cn.; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. myzheng@simm.ac.cn., Zhang SL; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. slzhang@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. slzhang@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Feb; Vol. 47 (2), pp. 504-517. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-025-01657-w