View in EDS

Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia.

Saved in:
Bibliographic Details
Title: Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia.
Authors: Chu SQ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Chen YJ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Yang RR; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China., Teng D; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhou GZ; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China., Zhang YY; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China., Niu BY; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Xu JH; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China., Lin KX; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Yang XY; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Li XT; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. lixutong@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. lixutong@simm.ac.cn., Zheng MY; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. myzheng@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. myzheng@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. myzheng@simm.ac.cn.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. myzheng@simm.ac.cn.; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China. myzheng@simm.ac.cn.; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. myzheng@simm.ac.cn., Zhang SL; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. slzhang@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. slzhang@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Feb; Vol. 47 (2), pp. 504-517. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41034402
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Chu+SQ%22">Chu SQ</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Yang+RR%22">Yang RR</searchLink>; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.<br /><searchLink fieldCode="AU" term="%22Teng+D%22">Teng D</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhou+GZ%22">Zhou GZ</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YY%22">Zhang YY</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.<br /><searchLink fieldCode="AU" term="%22Niu+BY%22">Niu BY</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Xu+JH%22">Xu JH</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.<br /><searchLink fieldCode="AU" term="%22Lin+KX%22">Lin KX</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Yang+XY%22">Yang XY</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+XT%22">Li XT</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. lixutong@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. lixutong@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+MY%22">Zheng MY</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. myzheng@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. myzheng@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. myzheng@simm.ac.cn.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. myzheng@simm.ac.cn.; School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China. myzheng@simm.ac.cn.; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. myzheng@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+SL%22">Zhang SL</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. slzhang@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. slzhang@simm.ac.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Feb; Vol. 47 (2), pp. 504-517. <i>Date of Electronic Publication: </i>2025 Oct 01.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41034402
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41401-025-01657-w
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 504
    Titles:
      – TitleFull: Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Chu SQ
      – PersonEntity:
          Name:
            NameFull: Chen YJ
      – PersonEntity:
          Name:
            NameFull: Yang RR
      – PersonEntity:
          Name:
            NameFull: Teng D
      – PersonEntity:
          Name:
            NameFull: Zhou GZ
      – PersonEntity:
          Name:
            NameFull: Zhang YY
      – PersonEntity:
          Name:
            NameFull: Niu BY
      – PersonEntity:
          Name:
            NameFull: Xu JH
      – PersonEntity:
          Name:
            NameFull: Lin KX
      – PersonEntity:
          Name:
            NameFull: Yang XY
      – PersonEntity:
          Name:
            NameFull: Li XT
      – PersonEntity:
          Name:
            NameFull: Zheng MY
      – PersonEntity:
          Name:
            NameFull: Zhang SL
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1745-7254
          Numbering:
            – Type: volume
              Value: 47
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Acta pharmacologica Sinica
              Type: main
ResultId 1