Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk.

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Title: Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk.
Authors: Millette A; Division of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc., (RFMH) / New York State Psychiatric Institute (NYSPI), Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, NY, 10032, USA., van Dijk MT; Division of Translational Epidemiology and Mental Health Equity, Research Foundation for Mental Hygiene, Inc., (RFMH) / New York State Psychiatric Institute (NYSPI), Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, NY, 10032, USA., Pokhvisneva I; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada., Li Y; Division of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc., (RFMH) / New York State Psychiatric Institute (NYSPI), Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, NY, 10032, USA., Thompson R; Division of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc., (RFMH) / New York State Psychiatric Institute (NYSPI), Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, NY, 10032, USA., Patel S; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada., Bagot RC; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada.; Department of Psychology, McGill University, Montreal, QC, Canada., Naray-Fejes-Toth A; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA., Fejes-Toth G; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA., Silveira PP; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada., Turecki G; McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada., Lopez JP; Department of Neuroscience, Karolinska Institutet, Stockholm, 17165, Sweden., Anacker C; Division of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc., (RFMH) / New York State Psychiatric Institute (NYSPI), Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, NY, 10032, USA. ca2635@cumc.columbia.edu.; Division of Developmental Neuroscience, Research Foundation for Mental Hygiene, Inc., (RFMH) / New York State Psychiatric Institute (NYSPI), Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, NY, 10032, USA. ca2635@cumc.columbia.edu.; Columbia University Stem Cell Initiative (CSCI), Columbia University Irving Medical Center (CUIMC), New York, NY, 10032, USA. ca2635@cumc.columbia.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2025 Dec; Vol. 30 (12), pp. 6079-6089. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03269-6