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Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue.

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Title: Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue.
Authors: Andrews R; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Oncology R&D, AstraZeneca, Cambridge, UK.; Department of Chemistry, University of Zurich, Zurich, Switzerland., Fu B; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA., Toomey CE; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK., Breiter JC; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Lachica J; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK., Beckwith JS; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA., Tian R; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Brock EE; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA., Needham LM; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Cambridge Advanced Imaging Centre, University of Cambridge, Cambridge, UK., Chant GJ; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA., Loiseau C; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Deconfin A; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Department of Engineering Physics, Polytechnique Montréal, Montréal, Québec, Canada., Baspin K; Department of Engineering Physics, Polytechnique Montréal, Montréal, Québec, Canada., Popovic R; The Francis Crick Institute, London, UK., Evans J; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; The Francis Crick Institute, London, UK., Goh Y; The Francis Crick Institute, London, UK., Kurt B; Achucarro Basque Center for Neuroscience, Leioa, Spain., Senicar L; UK Dementia Research Institute, University College London, London, UK., Edmonds M; UK Dementia Research Institute, University College London, London, UK., Bartels T; UK Dementia Research Institute, University College London, London, UK., Bengoa-Vergniory N; Achucarro Basque Center for Neuroscience, Leioa, Spain.; Ikerbasque-Basque Foundation for Science, Bilbao, Spain.; Department of Neuroscience, University of the Basque Country, Leioa, Spain., Magill PJ; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Jaunmuktane Z; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, UK., Freeman OJ; Neuroscience BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; MSD R&D Innovation Centre, London, UK., Taylor BJM; Oncology R&D, AstraZeneca, Cambridge, UK., Hardy J; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, London, UK., Lashley T; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, London, UK., Ryten M; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK.; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Vendruscolo M; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Wood NW; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK., Weiss LE; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA. lucien.weiss@polymtl.ca.; Department of Engineering Physics, Polytechnique Montréal, Montréal, Québec, Canada. lucien.weiss@polymtl.ca., Gandhi S; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA. sonia.gandhi@crick.ac.uk.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK. sonia.gandhi@crick.ac.uk.; The Francis Crick Institute, London, UK. sonia.gandhi@crick.ac.uk., Lee SF; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. sl591@cam.ac.uk.; Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD, USA. sl591@cam.ac.uk.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Jun; Vol. 10 (6), pp. 1222-1234. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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