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Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma.

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Title: Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma.
Authors: Frey A; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA., Clulo K; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Fei Y; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Dumit TC; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA., Scallo F; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA., Allen JW; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA., Chang E; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Perry CJ; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Wirth LV; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA., Jacobs D; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA., Braun DA; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA., Bosenberg MW; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT 06511, USA., Tran TT; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Clune J; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA., Kluger HM; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Olino K; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address: kelly.olino@yale.edu., Ishizuka JJ; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address: jeffrey.ishizuka@yale.edu.
Source: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116359. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2025.116359