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Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma.

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Title: Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma.
Authors: Frey A; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA., Clulo K; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Fei Y; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Dumit TC; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA., Scallo F; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA., Allen JW; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA., Chang E; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Perry CJ; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Wirth LV; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA., Jacobs D; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA., Braun DA; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA., Bosenberg MW; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT 06511, USA., Tran TT; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Clune J; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA., Kluger HM; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA., Olino K; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address: kelly.olino@yale.edu., Ishizuka JJ; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address: jeffrey.ishizuka@yale.edu.
Source: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116359. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Frey+A%22">Frey A</searchLink>; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Clulo+K%22">Clulo K</searchLink>; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Fei+Y%22">Fei Y</searchLink>; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Dumit+TC%22">Dumit TC</searchLink>; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Scallo+F%22">Scallo F</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Allen+JW%22">Allen JW</searchLink>; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Chang+E%22">Chang E</searchLink>; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Perry+CJ%22">Perry CJ</searchLink>; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Wirth+LV%22">Wirth LV</searchLink>; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Jacobs+D%22">Jacobs D</searchLink>; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Braun+DA%22">Braun DA</searchLink>; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Bosenberg+MW%22">Bosenberg MW</searchLink>; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Tran+TT%22">Tran TT</searchLink>; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Clune+J%22">Clune J</searchLink>; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Kluger+HM%22">Kluger HM</searchLink>; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA.<br /><searchLink fieldCode="AU" term="%22Olino+K%22">Olino K</searchLink>; Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address: kelly.olino@yale.edu.<br /><searchLink fieldCode="AU" term="%22Ishizuka+JJ%22">Ishizuka JJ</searchLink>; Department of Medicine (Oncology), Yale School of Medicine, New Haven, CT 06511, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address: jeffrey.ishizuka@yale.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116359. <i>Date of Electronic Publication: </i>2025 Oct 01.
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