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Exploring the potential of new acetylated unsaturated Oxindole derivatives as multi-target inhibitors for BACE1 and BuChE.

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Title: Exploring the potential of new acetylated unsaturated Oxindole derivatives as multi-target inhibitors for BACE1 and BuChE.
Authors: Montargil CA; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; CNC-UC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University Coimbra, Coimbra, Portugal; Coimbra Chemistry Centre - Institute of Molecular Sciences (CQC-IMS), Chemistry Department, University of Coimbra, 3004-535 Coimbra, Portugal., Pinto M; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; CNC-UC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University Coimbra, Coimbra, Portugal; Coimbra Chemistry Centre - Institute of Molecular Sciences (CQC-IMS), Chemistry Department, University of Coimbra, 3004-535 Coimbra, Portugal., Resende R; CNC-UC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University Coimbra, Coimbra, Portugal., Carreiro EP; LAQV-REQUIMTE, University of Évora, Institute of Research and Advanced Training (IIFA), 7000-671 Évora, Portugal., García-Sosa AT; Institute of Chemistry, University of Tartu, Ravila 14 A, Tartu 50411, Estonia., Santos AE; CNC-UC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University Coimbra, Coimbra, Portugal; Laboratory of Biochemistry and Biology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal., Burke AJ; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; CNC-UC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University Coimbra, Coimbra, Portugal; Coimbra Chemistry Centre - Institute of Molecular Sciences (CQC-IMS), Chemistry Department, University of Coimbra, 3004-535 Coimbra, Portugal. Electronic address: ajburke@ff.uc.pt.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118419. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3391
DOI:10.1016/j.bmc.2025.118419