Preliminary qualification of a machine learning-based assessment of the tumor immune infiltrate as a predictor of outcome in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab.

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Title: Preliminary qualification of a machine learning-based assessment of the tumor immune infiltrate as a predictor of outcome in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab.
Authors: Scheiner B; Imperial College London Department of Surgery and Cancer, London, UK.; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Lombardi P; Imperial College London Department of Surgery and Cancer, London, UK.; Phase 1 Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., D'Alessio A; Imperial College London Department of Surgery and Cancer, London, UK., Kim G; Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea., Tafavvoghi M; Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway., Petrenko O; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Ukrainian Institute for Systems Biology and Medicine, 04119 Kyiv, Ukraine., Goldin RD; Imperial College London Department of Surgery and Cancer, London, UK., Fulgenzi CAM; Imperial College London Department of Surgery and Cancer, London, UK., Torkpour A; Imperial College London Department of Surgery and Cancer, London, UK., Balcar L; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Mauri FA; Imperial College London Department of Surgery and Cancer, London, UK., Pomej K; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Himmelsbach V; Department of Gastroenterology and Hepatology, University Hospital Frankfurt, Frankfurt, Germany., Barsch M; Department of Internal Medicine II, Medical Center - University of Freiburg, Freiburg, Germany., Celsa C; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy., Cabibbo G; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy., Cheon J; Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea., Krall A; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Steiermark, Austria., Hucke F; Internal Medicine and Gastroenterology (IMuG), Including Centralized Emergency Service (ZAE), Klinikum Klagenfurt am Wörthersee, Klagenfurt, Kärnten, Austria., Di Tommaso L; Department of Pathology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Bernasconi M; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Rimassa L; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Samson A; Leeds Institute of Medical Research at St James's (LIMR), School of Medicine, Faculty of Medicine and Health, University of Leeds, St James's University Hospita, Leeds, UK., Stefanini B; Department of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy., Mozayani B; Department of Pathology, Medical University of Vienna, Vienna, Austria., Trauner M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Lackner C; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Stauber R; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Steiermark, Austria., Vasuri F; Pathology Unit, IRCCS - Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy., Piscaglia F; Department of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy.; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy., Bengsch B; Department of Internal Medicine II, Medical Center - University of Freiburg, Freiburg, Germany., Finkelmeier F; Department of Gastroenterology and Hepatology, University Hospital Frankfurt, Frankfurt, Germany., Peck-Radosavljevic M; Internal Medicine and Gastroenterology (IMuG), Including Centralized Emergency Service (ZAE), Klinikum Klagenfurt am Wörthersee, Klagenfurt, Kärnten, Austria., Rasmussen Busund LT; Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway., Marafioti T; Department of Histopathology, University College London Hospital, London, UK., Rahbari M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Pinter M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Chon HJ; Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea david.pinato@imperial.ac.uk hongjaechon@gmail.com., Rakaee M; Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway.; Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway., Pinato DJ; Imperial College London Department of Surgery and Cancer, London, UK david.pinato@imperial.ac.uk hongjaechon@gmail.com.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Oct 05; Vol. 13 (10). Date of Electronic Publication: 2025 Oct 05.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-1426
DOI:10.1136/jitc-2024-010975