HIF1 activity in photoreceptors drives type 3 neovascularization and retinal atrophy in a new mouse model of age-related macular degeneration.

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Title: HIF1 activity in photoreceptors drives type 3 neovascularization and retinal atrophy in a new mouse model of age-related macular degeneration.
Authors: Geiger F; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland., Heigl T; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland., Merolla L; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland., Yong M; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland.; Neuroscience Center, University of Zürich, Zürich, Switzerland., Wögenstein GM; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland.; Neuroscience Center, University of Zürich, Zürich, Switzerland., Govers LP; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland., Tsioti I; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland., Fottner A; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland., Samardzija M; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland., Grimm C; Lab for Retinal Cell Biology, Dept. Ophthalmology, University of Zürich, Zürich, Switzerland. cgrimm@opht.uzh.ch.; Neuroscience Center, University of Zürich, Zürich, Switzerland. cgrimm@opht.uzh.ch.
Source: Cell death & disease [Cell Death Dis] 2025 Oct 06; Vol. 16 (1), pp. 687. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-025-08028-7