Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening.
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| Title: | Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening. |
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| Authors: | Holmqvist A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Kocaturk NM; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Duncan C; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK., Riley J; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK., Baginski S; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK., Marsh G; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK., Cresser-Brown J; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK., Maple H; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK., Juvonen K; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Sathe G; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Morrice N; Division of Neuroscience, School of Medicine, IMS/WTB Complex, University of Dundee, Dundee, UK., Sutherland C; School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK., Read KD; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK., Farnaby W; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK. w.farnaby@dundee.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Oct 06; Vol. 16 (1), pp. 8857. Date of Electronic Publication: 2025 Oct 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-63928-8 |
