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Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening.

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Title: Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening.
Authors: Holmqvist A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Kocaturk NM; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Duncan C; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK., Riley J; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK., Baginski S; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK., Marsh G; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK., Cresser-Brown J; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK., Maple H; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK., Juvonen K; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Sathe G; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Morrice N; Division of Neuroscience, School of Medicine, IMS/WTB Complex, University of Dundee, Dundee, UK., Sutherland C; School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK., Read KD; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK., Farnaby W; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK. w.farnaby@dundee.ac.uk.
Source: Nature communications [Nat Commun] 2025 Oct 06; Vol. 16 (1), pp. 8857. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Holmqvist+A%22">Holmqvist A</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Kocaturk+NM%22">Kocaturk NM</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Duncan+C%22">Duncan C</searchLink>; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Riley+J%22">Riley J</searchLink>; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Baginski+S%22">Baginski S</searchLink>; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Marsh+G%22">Marsh G</searchLink>; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Cresser-Brown+J%22">Cresser-Brown J</searchLink>; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Maple+H%22">Maple H</searchLink>; Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Juvonen+K%22">Juvonen K</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Sathe+G%22">Sathe G</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Morrice+N%22">Morrice N</searchLink>; Division of Neuroscience, School of Medicine, IMS/WTB Complex, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Sutherland+C%22">Sutherland C</searchLink>; School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Farnaby+W%22">Farnaby W</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK. w.farnaby@dundee.ac.uk.
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