Within-host genetic diversity of pneumococcal serotype 3 during one-year prolonged carriage in a healthy adult.

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Title: Within-host genetic diversity of pneumococcal serotype 3 during one-year prolonged carriage in a healthy adult.
Authors: Sibale LL; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi. lsibale@mlw.mw.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. lsibale@mlw.mw.; Parasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. lsibale@mlw.mw., Lo SW; Parasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, UK.; The Great Ormond Street Institute of Child Health, University College London, London, UK., Kalata N; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi., Nyazika TK; Department of Biomedical Sciences and Physiology, School of Life Sciences, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK., Mitole N; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi., Dyster V; Parasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Kusakala A; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi., Khwiya M; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi., Sagawa G; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi., Phiri JA; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Kalizang'oma A; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.; Research Department of Infection, Division of Infection and Immunity, University College London, London, UK., Swarthout TD; Research Department of Infection, Division of Infection and Immunity, University College London, London, UK., Malisita K; Lighthouse-Queen Elizabeth Hospital and Gateway Health Centre, Blantyre, Malawi., Kamng'ona AW; School of Life Science and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre, Malawi., Heyderman RS; Research Department of Infection, Division of Infection and Immunity, University College London, London, UK., Bentley SD; Parasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Kwambana-Adams BA; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.; Research Department of Infection, Division of Infection and Immunity, University College London, London, UK., Chaguza C; Parasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Research Department of Infection, Division of Infection and Immunity, University College London, London, UK.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Jambo KC; Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi. kondwani.jambo@lstmed.ac.uk.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. kondwani.jambo@lstmed.ac.uk.; School of Life Science and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre, Malawi. kondwani.jambo@lstmed.ac.uk.
Source: Nature communications [Nat Commun] 2025 Oct 07; Vol. 16 (1), pp. 8920. Date of Electronic Publication: 2025 Oct 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-63974-2