Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.

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Title: Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.
Authors: Akçimen F; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA., Paquette K; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Wild Crea P; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Step K; Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa.; South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town 7505, South Africa., Waldo E; Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44106, USA., Koretsky MJ; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; DataTecnica LLC, Washington, DC 20037, USA., Saffie-Awad P; Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035, Brazil.; Clínica Santa María, Santiago 7520378, Chile., Achoru C; Jos University Teaching Hospital, Jos, Plateau State 930105, Nigeria., Taiwo F; University College Hospital, Ibadan, Oyo State 200005, Nigeria., Ozomma S; Department of Internal Medicine, University of Calabar Teaching Hospital, Calabar, Cross River State 540281, Nigeria., Onwuegbuzie G; Department of Internal Medicine, University of Abuja, Gwagwalada, Federal Capital Territory 902101, Nigeria., Khani M; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Grant S; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Owolabi L; Department of Medicine, Bayero University, Kano, Kano State 700001, Nigeria., Okereke C; Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State 402109, Nigeria., Oshinaike O; Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos State P.M.B. 0001, Nigeria., Iwuozo E; Department of Internal Medicine, Benue State University, Makurdi, Benue State 970001, Nigeria., Akerman SC; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Lee PS; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA., Oyakhire S; Department of Internal Medicine, National Hospital Abuja, Abuja, Federal Capital Territory 900103, Nigeria., Osemwegie N; Department of Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State 500004, Nigeria., Daida K; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; Department of Neurology, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan., Abubakar S; Department of Medicine, Ahmadu Bello University, Zaria, Kaduna State 800001, Nigeria., Olusanya A; Department of Pharmacology, Therapeutics and Toxicology, College of Medicine University of Lagos, Idi-araba, Lagos State P.M.B 12003, Nigeria.; R-Jolad Hospital, Gbagada, Lagos 100254, Nigeria., Isayan M; Department of Neurology and Neurosurgery, National Institute of Health, Yerevan 0051, Armenia., Alvarez C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Traurig R; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Ogunmodede A; Neurology Unit, Department of Medicine, Federal Medical Center, Owo, Ondo State 341101, Nigeria., Samuel S; University of Maiduguri Teaching Hospital, Maiduguri, Borno State 600230, Nigeria., Makarious MB; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; DataTecnica LLC, Washington, DC 20037, USA., Sa'ad F; Federal Teaching Hospital, Gombe, Gombe State 760253, Nigeria., Olanigan R; Neurology Unit, Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos State 101233, Nigeria., Levine K; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; DataTecnica LLC, Washington, DC 20037, USA., Ogbimi EM; Department of Medicine, Faculty of Clinical Medicine, Delta State University, Abraka, Delta State 330105, Nigeria., Vitale D; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; DataTecnica LLC, Washington, DC 20037, USA., Odiase F; Department of Medicine, College of Medical Sciences, University of Benin, Benin City, Edo State 300242, Nigeria., Ojini F; Department of Medicine, Ahmadu Bello University, Zaria, Kaduna State 800001, Nigeria.; Department of Medicine, Neurology Unit, Lagos University Teaching Hospital, Idi-araba, Lagos State 102215, Nigeria., Odeniyi O; General Hospital, Lagos Island, Lagos State 102273, Nigeria., Fang ZH; German Center for Neurodegenerative Diseases, DZNE, Tübingen 72076, Germany., Obianozie N; University of Abuja Teaching Hospital, Gwagwalada, Federal Capital Territory 902101, Nigeria., Hall DA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA., Nwazor E; Department of Medicine, Rivers State University Teaching Hospital, Port Harcourt, Rivers State 500101, Nigeria., Xie T; University of Chicago Medicine, Department of Neurology, Chicago, IL 60637, USA., Nwaokorie F; Department of Pharmacology, Therapeutics and Toxicology, College of Medicine University of Lagos, Idi-araba, Lagos State P.M.B 12003, Nigeria., Padmanaban M; University of Chicago Medicine, Department of Neurology, Chicago, IL 60637, USA., Nwani P; Internal Medicine, Faculty of Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State 435101, Nigeria., Shamim EA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.; Department of Neurology, Mid-Atlantic Permanente Medical Group, Largo, MD 20774, USA.; Kaiser Permanente, Mid-Atlantic Permanente Research Institute, Washington, DC 20002, USA., Nnama A; Department of Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State 500004, Nigeria., Standaert D; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Komolafe M; Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State 220282, Nigeria., Dean M; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Osaigbovo G; Jos University Teaching Hospital, Jos, Plateau State 930105, Nigeria., Disbrow E; Department of Neurology, LSU Health Shreveport, LSU Health Shreveport Center for Brain Health, Shreveport, LA 71103, USA., Ishola I; Department of Medicine, College of Medical Sciences, University of Benin, Benin City, Edo State 300242, Nigeria., Rawls A; Department of Neurology, University of Florida College of Medicine, Gainesville, Florida 32611, USA., Imarhiagbe F; Department of Medicine, Faculty of Clinical Medicine, Delta State University, Abraka, Delta State 330105, Nigeria., Chandra S; Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 20036, USA., Erameh C; Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State 312107, Nigeria., Hinson V; Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA., Louie N; Department of Clinical Research, Michael J Fox Foundation for Parkinson's Research, New York, NY 10163, USA., Idowu A; Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State 220282, Nigeria., Solle J; Department of Clinical Research, Michael J Fox Foundation for Parkinson's Research, New York, NY 10163, USA., Norris SA; Department of Neurology, Washington University in St Louis, St Louis, MO 63130, USA., Ibrahim A; Federal University of Health Sciences Teaching Hospital, Azare, Bauchi State 751102, Nigeria., Kilbane C; University Hospital in Cleveland Medical Center, Case Western Reserve University (UH), Cleveland, OH 44106, USA., Sukumar G; Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services, Bethesda, MD 20814, USA.; Center for Military Precision Health, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Shulman LM; Department of Neurology, University of Maryland, Baltimore, MD 21201, USA., Ezuduemoih D; Department of Medicine, Neurology Unit, Lagos University Teaching Hospital, Idi-araba, Lagos State 102215, Nigeria., Staisch J; Ochsner Clinic Foundation, New Orleans, LA 70124, USA., Breaux S; Ochsner Clinic Foundation, New Orleans, LA 70124, USA., Dalgard C; Henry M Jackson Foundation for the Advancement of Military Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.; The American Genome Center, Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Foster ER; Department of Neurology, Washington University in St Louis, St Louis, MO 63130, USA., Bello A; Division of Neurology, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State 234031, Nigeria., Ameri A; Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA., Real R; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.; UCL Movement Disorders Centre, University College London, London WC1N 3BG, UK., Ikwenu E; Department of Medicine, Neurology Unit, Lagos University Teaching Hospital, Idi-araba, Lagos State 102215, Nigeria., Morris HR; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.; National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.; Department of Neurology, Royal Free Hospital, London NW3 2QG, UK., Anyanwu R; Department of Pharmacology, Therapeutics and Toxicology, College of Medicine University of Lagos, Idi-araba, Lagos State P.M.B 12003, Nigeria., Furr Stimming E; Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 20036, USA., Billingsley K; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Alaofin W; Department of Medicine, University of Ilorin, Ilorin, Kwara State 240001, Nigeria., Alvarez Jerez P; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Agabi O; Department of Pharmacology, Therapeutics and Toxicology, College of Medicine University of Lagos, Idi-araba, Lagos State P.M.B 12003, Nigeria.; Department of Medicine, Neurology Unit, Lagos University Teaching Hospital, Idi-araba, Lagos State 102215, Nigeria., Hernandez DG; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA., Akinyemi R; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, 200212 Oyo State, Nigeria., Arepalli S; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA., Malik L; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Owolabi R; Neurology Unit, Department of Medicine, Federal Medical Center, Owo, Ondo State 341101, Nigeria., Nyandaiti Y; University of Maiduguri Teaching Hospital, Maiduguri, Borno State 600230, Nigeria., Leonard HL; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; DataTecnica LLC, Washington, DC 20037, USA., Wahab K; Department of Medicine, University of Ilorin, Ilorin, Kwara State 240001, Nigeria., Abiodun O; General Hospital, Isolo, Lagos State 100263, Nigeria., Hernandez CF; Universidad del Desarrollo, Centro de Genética y Genómica, Facultad de Medicina Clínica Alemana, Santiago 7610658, Chile., Abdulai F; University of Abuja Teaching Hospital, Gwagwalada, Federal Capital Territory 902101, Nigeria., Iwaki H; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; DataTecnica LLC, Washington, DC 20037, USA., Bardien S; Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa., Klein C; Institute of Neurogenetics and Department of Neurology, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck 23562, Germany., Hardy J; Reta Lila Weston Institute of Neurological Studies, University College London,London WC1N 1PJ, UK., Houlden H; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., Galvelis KG; Parkinson's Foundation, New York, NY 10018, USA., Nalls MA; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.; DataTecnica LLC, Washington, DC 20037, USA., Dahodwala N; Department of Neurology, Parkinson's Disease and Movement Disorder Center, University of Pennsylvania, Philadelphia, PA 19104, USA., Aamodt W; Department of Neurology, Parkinson's Disease and Movement Disorder Center, University of Pennsylvania, Philadelphia, PA 19104, USA., Hill E; Department of Neurology, University of Cincinnati, Cincinnati, OH 45221, USA., Espay A; Department of Neurology, University of Cincinnati, Cincinnati, OH 45221, USA., Factor S; Department of Neurology, Emory University, Atlanta, GA 30322, USA., Branson C; Department of Internal Medicine, Morehouse College, Atlanta, GA 30314, USA., Blauwendraat C; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Singleton AB; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA., Ojo O; Department of Pharmacology, Therapeutics and Toxicology, College of Medicine University of Lagos, Idi-araba, Lagos State P.M.B 12003, Nigeria.; Department of Medicine, Neurology Unit, Lagos University Teaching Hospital, Idi-araba, Lagos State 102215, Nigeria., Chahine LM; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Okubadejo N; Department of Pharmacology, Therapeutics and Toxicology, College of Medicine University of Lagos, Idi-araba, Lagos State P.M.B 12003, Nigeria.; Department of Medicine, Neurology Unit, Lagos University Teaching Hospital, Idi-araba, Lagos State 102215, Nigeria., Bandres-Ciga S; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Source: Brain : a journal of neurology [Brain] 2026 May 05; Vol. 149 (5), pp. 1537-1553.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1460-2156
DOI:10.1093/brain/awaf379