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Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer.

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Title: Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer.
Authors: Mittmann G; Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany., Laiouar-Pedari S; Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mehrtens HA; Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), Heidelberg, Germany., Haggenmüller S; Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bucher TC; Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), Heidelberg, Germany., Chanda T; Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany., Gaisa NT; Institute of Pathology, RWTH Aachen University, Aachen, Germany.; Institute of Pathology, University Hospital, University of Ulm, Ulm, Germany., Wagner M; Department of Pathology, University of Saarland, Homburg Saar Campus, Homburg Saar, Germany., Klamminger GG; Department of Pathology, University of Saarland, Homburg Saar Campus, Homburg Saar, Germany., Rau TT; Heinrich-Heine-University and University Hospital Düsseldorf, Düsseldorf, Germany., Neppl C; Heinrich-Heine-University and University Hospital Düsseldorf, Düsseldorf, Germany., Compérat EM; Department of Pathology, Medical University of Vienna, Vienna, Austria., Gocht A; Institute of Pathology, University Hospital Schleswig-Holstein, Lübeck, Germany., Haemmerle M; Institute of Pathology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany., Rupp NJ; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Westhoff J; Institute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany., Krücken I; Institute of Pathology, Klinikum Bremen Mitte, Bremen, Germany.; PathoNext GmbH, Leipzig, Germany., Seidl M; Heinrich-Heine-University and University Hospital Düsseldorf, Düsseldorf, Germany., Schürch CM; Department of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany., Bauer M; Institute of Pathology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany., Solass W; Institute of Tissue Medicine and Pathology, University Bern, Bern, Switzerland., Tam YC; Institute of Pathology, Georgius Agricola Foundation Ruhr, Ruhr University Bochum, Bochum, Germany., Weber F; Institute of Pathology, University of Regensburg, Regensburg, Germany., Grobholz R; Faculty of Medicine, University of Zurich, Zurich, Switzerland.; Institute of Pathology, Cantonal Hospital Aarau, Aarau, Switzerland., Augustyniak J; Laborteam Pathology, Goldach, Switzerland., Kalinski T; Institute of Pathology, Brandenburg Medical School Theodor Fontane, University Hospital Brandenburg an der Havel, Brandenburg an der Havel, Germany., Hörner C; Institute for Pathology, University Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Mertz KD; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine (DBM), Pathology of Infectious and Immunologic Diseases, University of Basel, Basel, Switzerland., Döring C; Pathology Zwickau, MVZ diagnosticum Stollberg, Zweigpraxis Zwickau, Zwickau, Germany., Erbersdobler A; Institute of Pathology, University Medicine Rostock, Rostock, Germany., Deubler G; Institute of Pathology, Kreiskliniken Reutlingen, Reutlingen, Germany., Bremmer F; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Sommer U; Institute of Pathology, University Hospital of Dresden, Dresden, Germany., Brodhun M; Institute of Pathology and Neuropathology, HELIOS Klinikum Erfurt, Erfurt, Germany., Griffin J; School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Lenon MSL; Department of Pathology, University of Santo Tomas Hospital, Manila, Philippines.; Department of Pathology and Laboratory Medicine, National Kidney and Transplant Institute, Quezon City, Philippines., Trpkov K; Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Rockyview General Hospital, Calgary, AB, Canada., Cheng L; Department of Pathology and Laboratory Medicine, Department of Surgery (Urology), Brown University Warren Alpert Medical School, the Legorreta Cancer Center at Brown University, and Brown University Health, Providence, RI, USA., Chen F; Department of Pathology, NYU Langone Health, New York, NY, USA., Levi A; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Cai G; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Nguyen TQ; Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands., Amin A; Department of Pathology, Warren Alpert Medical School of Brown University, Providence, RI, USA., Cimadamore A; Pathological Anatomy, University of Udine, Udine, Friuli-Venezia Giulia, Italy., Shabaik A; Department of Pathology, UC San Diego School of Medicine, La Jolla, CA, USA., Manucha V; Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA., Ahmad N; University of South Florida, Morsani College of Medicine, Department of Pathology & Cell Biology and James A. Haley Veterans' Hospital, Tampa, FL, USA., Messias N; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA., Sanguedolce F; Department of Pathology, University of Foggia, Foggia, Italy., Taheri D; Isfahan Kidney Diseases Research Center, Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.; Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran., Baraban E; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Jia L; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Shah RB; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Siadat F; Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Rockyview General Hospital, Calgary, AB, Canada., Swarbrick N; Department of Anatomical Pathology, PathWest Laboratory Medicine WA, Perth, WA, Australia.; Division of Pathology and Laboratory Medicine, UWA Medical School, Crawley, WA, Australia., Park K; Department of Pathology, NYU Langone Health, New York, NY, USA., Hassan O; Department of Pathology, Henry Ford Health System, Detroit, MI, USA., Sakhaie S; Department of Anatomical Pathology, Frankston Laboratory, Dorevitch Pathology, Frankston, VIC, Australia., Downes MR; Anatomic Pathology, Precision Diagnostics & Therapeutics Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Miyamoto H; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Williamson SR; Department of Pathology, Diagnostics Institute, Cleveland Clinic, Cleveland, OH, USA., Holland-Letz T; Division of Biostatistics, German Cancer Research Center(DKFZ), Heidelberg, Germany., Wies C; Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty, Heidelberg University, Heidelberg, Germany., Schneider CV; Department of Internal Medicine, University Hospital Aachen, RWTH University of Aachen, Aachen, Germany., Kather JN; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.; Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.; Pathology & Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Tolkach Y; Institute of Pathology, University Hospital Cologne, Cologne, Germany.; Medical Faculty, University of Cologne, Cologne, Germany., Brinker TJ; Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), Heidelberg, Germany. titus.brinker@dkfz.de.
Source: Nature communications [Nat Commun] 2025 Oct 08; Vol. 16 (1), pp. 8959. Date of Electronic Publication: 2025 Oct 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-64712-4