mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.
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| Title: | mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis. |
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| Authors: | Babaei-Jadidi R; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK. roya.babaei-jadidi@nottingham.ac.uk., Clements D; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK., Wu Y; Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, USA., Chen K; Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, USA., Miller S; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK., Platé M; Centre for Inflammation and Tissue Repair, University College London, London, UK., Lim K; The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Life Sciences, Korea University, 145 Anam-Ro, Seoungbuk-Gu, Seoul, South Korea., Rue R; Division of Pulmonary and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA., Krymskaya VP; Division of Pulmonary and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA., Chambers R; Centre for Inflammation and Tissue Repair, University College London, London, UK., Rawlins EL; The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Xu Y; Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA., Johnson SR; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK. simon.johnson@nottingham.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Oct 09; Vol. 16 (1), pp. 8996. Date of Electronic Publication: 2025 Oct 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64036-3 |
