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mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.

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Title: mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.
Authors: Babaei-Jadidi R; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK. roya.babaei-jadidi@nottingham.ac.uk., Clements D; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK., Wu Y; Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, USA., Chen K; Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, USA., Miller S; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK., Platé M; Centre for Inflammation and Tissue Repair, University College London, London, UK., Lim K; The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Life Sciences, Korea University, 145 Anam-Ro, Seoungbuk-Gu, Seoul, South Korea., Rue R; Division of Pulmonary and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA., Krymskaya VP; Division of Pulmonary and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA., Chambers R; Centre for Inflammation and Tissue Repair, University College London, London, UK., Rawlins EL; The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Xu Y; Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA., Johnson SR; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK. simon.johnson@nottingham.ac.uk.
Source: Nature communications [Nat Commun] 2025 Oct 09; Vol. 16 (1), pp. 8996. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.
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  Data: <searchLink fieldCode="AU" term="%22Babaei-Jadidi+R%22">Babaei-Jadidi R</searchLink>; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK. roya.babaei-jadidi@nottingham.ac.uk.<br /><searchLink fieldCode="AU" term="%22Clements+D%22">Clements D</searchLink>; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Neonatology and Pulmonary Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.<br /><searchLink fieldCode="AU" term="%22Miller+S%22">Miller S</searchLink>; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Platé+M%22">Platé M</searchLink>; Centre for Inflammation and Tissue Repair, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lim+K%22">Lim K</searchLink>; The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Life Sciences, Korea University, 145 Anam-Ro, Seoungbuk-Gu, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Rue+R%22">Rue R</searchLink>; Division of Pulmonary and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Krymskaya+VP%22">Krymskaya VP</searchLink>; Division of Pulmonary and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Chambers+R%22">Chambers R</searchLink>; Centre for Inflammation and Tissue Repair, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Rawlins+EL%22">Rawlins EL</searchLink>; The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Divisions of Pulmonary Biology and Biomedical Informatics, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+SR%22">Johnson SR</searchLink>; Centre for Respiratory Research, School of Medicine, University of Nottingham, Nottingham, UK. simon.johnson@nottingham.ac.uk.
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