Targeting the HIF1A-UCA1-PTBP3 axis: a potential therapeutic strategy for head and neck cancer.

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Title: Targeting the HIF1A-UCA1-PTBP3 axis: a potential therapeutic strategy for head and neck cancer.
Authors: Sim LC; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C., Kuo YZ; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.; Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C., Cheng TC; Department of Otolaryngology, An Nan Hospital, China Medical University, Tainan, Taiwan, R.O.C., Chen CL; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C., Hsiao JR; Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C., Ooi MX; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C., Yun Z; Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, U.S.A., Kao HY; Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, U.S.A., Tsai ST; Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.. T602511@mail.ncku.edu.tw.; Research Department, Changhua Christian Hospital, Changhua City, Taiwan, R.O.C.. T602511@mail.ncku.edu.tw., Wu LW; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.. liwhawu@mail.ncku.edu.tw.; Department of Laboratory Science and Technology, College of Health Sciences,, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.. liwhawu@mail.ncku.edu.tw.
Source: BMC cancer [BMC Cancer] 2025 Oct 09; Vol. 25 (1), pp. 1536. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1471-2407
DOI:10.1186/s12885-025-15020-z