Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning.
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| Title: | Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning. |
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| Authors: | Du C; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China., Zhang Y; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China., Zhu W; Department of Biomedical Engineering, College of Life Science and Techology, Huazhong University of Science and Technology, Wuhan 430016, China., Liu X; Department of Laboratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China., Liu N; Department of Biomedical Engineering, College of Life Science and Techology, Huazhong University of Science and Technology, Wuhan 430016, China., He Z; Wuhan Center for Control & Prevention, Wuhan 430060, China., Liu J; Wuhan Center for Control & Prevention, Wuhan 430060, China., Lin Y; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China., Hu X; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China. |
| Source: | Analytical chemistry [Anal Chem] 2025 Oct 21; Vol. 97 (41), pp. 22817-22825. Date of Electronic Publication: 2025 Oct 10. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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