Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury.

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Title: Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury.
Authors: Liu YX; Department of Cell Biology, School of Life Science, Central South University, Changsha, 410013, China.; Department of Nephrology, Xiangya Hospital of Central South University, Changsha, 410028, China., Wang Q; Department of Cell Biology, School of Life Science, Central South University, Changsha, 410013, China., Xiangyang ZY; Department of Cell Biology, School of Life Science, Central South University, Changsha, 410013, China., Long JY; Department of Cell Biology, School of Life Science, Central South University, Changsha, 410013, China., Huang H; Department of Cell Biology, School of Life Science, Central South University, Changsha, 410013, China.; Department of Nephrology, Xiangya Hospital of Central South University, Changsha, 410028, China., Fan LL; Department of Cell Biology, School of Life Science, Central South University, Changsha, 410013, China. swfanliangliang@csu.edu.cn.
Source: Molecular biomedicine [Mol Biomed] 2025 Oct 10; Vol. 6 (1), pp. 78. Date of Electronic Publication: 2025 Oct 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-8651
DOI:10.1186/s43556-025-00317-z