A novel scalable method for the production of rennet-treated milk-derived extracellular vesicles for improved curcumin oral delivery.

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Title: A novel scalable method for the production of rennet-treated milk-derived extracellular vesicles for improved curcumin oral delivery.
Authors: Schifano E; Department of Biology and Biotechnologies 'C. Darwin', Sapienza University of Rome, Rome, Italy., Vari F; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy., Buccini L; Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.; Research Center of Nanotechnologies for Engineering (CNIS), Sapienza University of Rome, Rome, Italy., Karimova M; Department of Biology and Biotechnologies 'C. Darwin', Sapienza University of Rome, Rome, Italy., Syman K; Department of Biology Faculty of Natural Science and Geography, Abai KazakhNational Pedagogical University Almaty, Almaty, Kazakhstan., Varnadyan D; Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy., Uccelletti D; Department of Biology and Biotechnologies 'C. Darwin', Sapienza University of Rome, Rome, Italy., Dinarelli S; Institute for the Structure of Matter, National Research Council, Roma, Italy., Zuccotti M; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Alfieri A; Centro Grandi Strumenti, University of Pavia, Pavia, Italy., Sennato S; Institute for Complex Systems (ISC)-CNR and Physics Department, Sapienza University, Rome, Italy., Mura F; Research Center of Nanotechnologies for Engineering (CNIS), Sapienza University of Rome, Rome, Italy., Rossi M; Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.; Research Center of Nanotechnologies for Engineering (CNIS), Sapienza University of Rome, Rome, Italy., Dini L; Department of Biology and Biotechnologies 'C. Darwin', Sapienza University of Rome, Rome, Italy. luciana.dini@uniroma1.it.; Research Center of Nanotechnologies for Engineering (CNIS), Sapienza University of Rome, Rome, Italy. luciana.dini@uniroma1.it., Tacconi S; Department of Biology and Biotechnologies 'C. Darwin', Sapienza University of Rome, Rome, Italy. stefano.tacconi@uniroma1.it.; Research Center of Nanotechnologies for Engineering (CNIS), Sapienza University of Rome, Rome, Italy. stefano.tacconi@uniroma1.it.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Oct 10; Vol. 23 (1), pp. 656. Date of Electronic Publication: 2025 Oct 10.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1477-3155
DOI:10.1186/s12951-025-03724-0