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Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease.

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Title: Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease.
Authors: Nice R; Blood Sciences Academic Department, Royal Devon University Healthcare Trust, Exeter, United Kingdom.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom., Lin S; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., Chanchlani N; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., Bewshea C; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom., Kennedy NA; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., Ahmad T; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., Winyard PG; Inflammation Research Group, University of Exeter Medical School, Exeter, United Kingdom., Goodhand J; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., McDonald TJ; Blood Sciences Academic Department, Royal Devon University Healthcare Trust, Exeter, United Kingdom.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.
Source: The journal of applied laboratory medicine [J Appl Lab Med] 2025 Nov 04; Vol. 10 (6), pp. 1580-1592.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101693884 Publication Model: Print Cited Medium: Print ISSN: 2576-9456 (Print) Linking ISSN: 24757241 NLM ISO Abbreviation: J Appl Lab Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2576-9456
DOI:10.1093/jalm/jfaf149