Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease.
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| Title: | Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease. |
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| Authors: | Nice R; Blood Sciences Academic Department, Royal Devon University Healthcare Trust, Exeter, United Kingdom.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom., Lin S; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., Chanchlani N; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., Bewshea C; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom., Kennedy NA; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., Ahmad T; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., Winyard PG; Inflammation Research Group, University of Exeter Medical School, Exeter, United Kingdom., Goodhand J; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom., McDonald TJ; Blood Sciences Academic Department, Royal Devon University Healthcare Trust, Exeter, United Kingdom.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom. |
| Source: | The journal of applied laboratory medicine [J Appl Lab Med] 2025 Nov 04; Vol. 10 (6), pp. 1580-1592. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101693884 Publication Model: Print Cited Medium: Print ISSN: 2576-9456 (Print) Linking ISSN: 24757241 NLM ISO Abbreviation: J Appl Lab Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41081582 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nice+R%22">Nice R</searchLink>; Blood Sciences Academic Department, Royal Devon University Healthcare Trust, Exeter, United Kingdom.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chanchlani+N%22">Chanchlani N</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bewshea+C%22">Bewshea C</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kennedy+NA%22">Kennedy NA</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ahmad+T%22">Ahmad T</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Winyard+PG%22">Winyard PG</searchLink>; Inflammation Research Group, University of Exeter Medical School, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Goodhand+J%22">Goodhand J</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom.; Department of Gastroenterology, Royal Devon University Healthcare Trust, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McDonald+TJ%22">McDonald TJ</searchLink>; Blood Sciences Academic Department, Royal Devon University Healthcare Trust, Exeter, United Kingdom.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, United Kingdom. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101693884%22">The journal of applied laboratory medicine</searchLink> [J Appl Lab Med] 2025 Nov 04; Vol. 10 (6), pp. 1580-1592. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101693884 <i>Publication Model: </i>Print <i>Cited Medium: </i>Print <i>ISSN: </i>2576-9456 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224757241%22">24757241 </searchLink><i>NLM ISO Abbreviation: </i>J Appl Lab Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41081582 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/jalm/jfaf149 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1580 Titles: – TitleFull: Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nice R – PersonEntity: Name: NameFull: Lin S – PersonEntity: Name: NameFull: Chanchlani N – PersonEntity: Name: NameFull: Bewshea C – PersonEntity: Name: NameFull: Kennedy NA – PersonEntity: Name: NameFull: Ahmad T – PersonEntity: Name: NameFull: Winyard PG – PersonEntity: Name: NameFull: Goodhand J – PersonEntity: Name: NameFull: McDonald TJ IsPartOfRelationships: – BibEntity: Dates: – D: 04 M: 11 Text: 2025 Nov 04 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 2576-9456 Numbering: – Type: volume Value: 10 – Type: issue Value: 6 Titles: – TitleFull: The journal of applied laboratory medicine Type: main |
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