MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death.
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| Title: | MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death. |
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| Authors: | Nguyen M; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Collier JJ; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Ignatenko O; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Morin G; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Goyon V; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada., Janer A; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada., Tiefensee Ribeiro C; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Milnerwood AJ; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada., Huang S; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montréal, Quebec, Canada., Desjardins M; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montréal, Quebec, Canada., McBride HM; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada. heidi.mcbride@mcgill.ca.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. heidi.mcbride@mcgill.ca. |
| Source: | Nature cell biology [Nat Cell Biol] 2025 Oct; Vol. 27 (10), pp. 1708-1724. Date of Electronic Publication: 2025 Oct 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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