Influenza vaccine based on AS03-adjuvanted chimeric HA induces long-lived stalk-specific plasma cells in bone marrow and lymph nodes of nonhuman primates.

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Title: Influenza vaccine based on AS03-adjuvanted chimeric HA induces long-lived stalk-specific plasma cells in bone marrow and lymph nodes of nonhuman primates.
Authors: Akhtar A; Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA., Styles TM; Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA., Gu C; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA., León AN; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Tharp GK; Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, USA., Stokdyk K; Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA., Abbad A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hirst C; Department of Biology, Emory University, Atlanta, GA, USA., Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Neumann G; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA., Richey ST; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ferguson JA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Mala U; Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA., Ahmed H; Department of Biology, Emory University, Atlanta, GA, USA., Han J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Carreño JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Davis CW; Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA., Antia R; Department of Biology, Emory University, Atlanta, GA, USA., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.; Pandemic Preparedness, Infection and Advanced Research Center, The University of Tokyo, Tokyo, Japan., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Science Outreach and Pandemic Preparedness, Medical University of Vienna, Vienna, Austria., Ahmed R; Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA., Amara RR; Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, USA. ramara@emory.edu.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. ramara@emory.edu.
Source: Nature immunology [Nat Immunol] 2025 Nov; Vol. 26 (11), pp. 2045-2058. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-025-02309-1