Tailor-made 3D in vitro maturation of early antral follicles uncovers cumulus-cell transcriptomic driver signature to predict oocyte competence.

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Title: Tailor-made 3D in vitro maturation of early antral follicles uncovers cumulus-cell transcriptomic driver signature to predict oocyte competence.
Authors: Rojo-Fleming C; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Konstantinidou F; Department of Neuroscience, Imaging and Clinical Sciences, School of Medicine and Health Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.; Unit of Molecular Genetics, Center for Advanced Studies and Technology (CAST), 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Peserico A; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Di Berardino C; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Capacchietti G; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Nardinocchi D; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Camerano Spelta Rapini C; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Russo V; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Bernabò N; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy., Capalbo A; Department of Neuroscience, Imaging and Clinical Sciences, School of Medicine and Health Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.; Unit of Molecular Genetics, Center for Advanced Studies and Technology (CAST), 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Stuppia L; Department of Neuroscience, Imaging and Clinical Sciences, School of Medicine and Health Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.; Unit of Molecular Genetics, Center for Advanced Studies and Technology (CAST), 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Gatta V; Department of Neuroscience, Imaging and Clinical Sciences, School of Medicine and Health Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.; Unit of Molecular Genetics, Center for Advanced Studies and Technology (CAST), 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Barboni B; Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2025 Oct 01; Vol. 16, pp. 1629815. Date of Electronic Publication: 2025 Oct 01 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-2392
DOI:10.3389/fendo.2025.1629815