Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.
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| Title: | Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding. |
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| Authors: | Simonetti F; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany.; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany., Zhong W; University of Zurich, Zurich, 8006, Switzerland., Hutten S; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany., Uliana F; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany., Schifferer M; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Center for Neuropathology and Prion Disease, Faculty of Medicine LMU, Munich, 81377, Germany., Rezaei A; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany., Ramirez LM; Max Planck Institute for Multidisciplinary Sciences, Göttingen, 37075, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, 37075, Germany., Hochmair J; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany., Sankar R; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany., Gopalan A; Johannes Gutenberg University (JGU), Biocenter, Light Microscopy Core Facility, Mainz, 55122, Germany.; Institute of Molecular Biology (IMB), Mainz, 55122, Germany., Kielisch F; Institute of Molecular Biology (IMB), Mainz, 55122, Germany., Riemenschneider H; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany., Ruf V; Center for Neuropathology and Prion Disease, Faculty of Medicine LMU, Munich, 81377, Germany., Schmidt C; Johannes Gutenberg University (JGU), Department of Chemistry-Biochemistry, Mainz, 55122, Germany., Simons M; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany., Zweckstetter M; Max Planck Institute for Multidisciplinary Sciences, Göttingen, 37075, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, 37075, Germany., Wegmann S; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany., Lashley T; UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK., Polymenidou M; University of Zurich, Zurich, 8006, Switzerland., Edbauer D; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany. dieter.edbauer@dzne.de.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany. dieter.edbauer@dzne.de.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany. dieter.edbauer@dzne.de., Dormann D; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany. ddormann@uni-mainz.de.; Institute of Molecular Biology (IMB), Mainz, 55122, Germany. ddormann@uni-mainz.de.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany. ddormann@uni-mainz.de. |
| Source: | The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (24), pp. 7395-7433. Date of Electronic Publication: 2025 Oct 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-025-00590-2 |
