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Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.

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Title: Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.
Authors: Simonetti F; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany.; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany., Zhong W; University of Zurich, Zurich, 8006, Switzerland., Hutten S; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany., Uliana F; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany., Schifferer M; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Center for Neuropathology and Prion Disease, Faculty of Medicine LMU, Munich, 81377, Germany., Rezaei A; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany., Ramirez LM; Max Planck Institute for Multidisciplinary Sciences, Göttingen, 37075, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, 37075, Germany., Hochmair J; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany., Sankar R; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany., Gopalan A; Johannes Gutenberg University (JGU), Biocenter, Light Microscopy Core Facility, Mainz, 55122, Germany.; Institute of Molecular Biology (IMB), Mainz, 55122, Germany., Kielisch F; Institute of Molecular Biology (IMB), Mainz, 55122, Germany., Riemenschneider H; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany., Ruf V; Center for Neuropathology and Prion Disease, Faculty of Medicine LMU, Munich, 81377, Germany., Schmidt C; Johannes Gutenberg University (JGU), Department of Chemistry-Biochemistry, Mainz, 55122, Germany., Simons M; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany., Zweckstetter M; Max Planck Institute for Multidisciplinary Sciences, Göttingen, 37075, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, 37075, Germany., Wegmann S; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany., Lashley T; UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK., Polymenidou M; University of Zurich, Zurich, 8006, Switzerland., Edbauer D; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany. dieter.edbauer@dzne.de.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany. dieter.edbauer@dzne.de.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany. dieter.edbauer@dzne.de., Dormann D; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany. ddormann@uni-mainz.de.; Institute of Molecular Biology (IMB), Mainz, 55122, Germany. ddormann@uni-mainz.de.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany. ddormann@uni-mainz.de.
Source: The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (24), pp. 7395-7433. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.
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  Data: <searchLink fieldCode="AU" term="%22Simonetti+F%22">Simonetti F</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany.; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany.<br /><searchLink fieldCode="AU" term="%22Zhong+W%22">Zhong W</searchLink>; University of Zurich, Zurich, 8006, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hutten+S%22">Hutten S</searchLink>; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany.<br /><searchLink fieldCode="AU" term="%22Uliana+F%22">Uliana F</searchLink>; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany.<br /><searchLink fieldCode="AU" term="%22Schifferer+M%22">Schifferer M</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Center for Neuropathology and Prion Disease, Faculty of Medicine LMU, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Rezaei+A%22">Rezaei A</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany.<br /><searchLink fieldCode="AU" term="%22Ramirez+LM%22">Ramirez LM</searchLink>; Max Planck Institute for Multidisciplinary Sciences, Göttingen, 37075, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, 37075, Germany.<br /><searchLink fieldCode="AU" term="%22Hochmair+J%22">Hochmair J</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany.<br /><searchLink fieldCode="AU" term="%22Sankar+R%22">Sankar R</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany.<br /><searchLink fieldCode="AU" term="%22Gopalan+A%22">Gopalan A</searchLink>; Johannes Gutenberg University (JGU), Biocenter, Light Microscopy Core Facility, Mainz, 55122, Germany.; Institute of Molecular Biology (IMB), Mainz, 55122, Germany.<br /><searchLink fieldCode="AU" term="%22Kielisch+F%22">Kielisch F</searchLink>; Institute of Molecular Biology (IMB), Mainz, 55122, Germany.<br /><searchLink fieldCode="AU" term="%22Riemenschneider+H%22">Riemenschneider H</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Ruf+V%22">Ruf V</searchLink>; Center for Neuropathology and Prion Disease, Faculty of Medicine LMU, Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+C%22">Schmidt C</searchLink>; Johannes Gutenberg University (JGU), Department of Chemistry-Biochemistry, Mainz, 55122, Germany.<br /><searchLink fieldCode="AU" term="%22Simons+M%22">Simons M</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany.<br /><searchLink fieldCode="AU" term="%22Zweckstetter+M%22">Zweckstetter M</searchLink>; Max Planck Institute for Multidisciplinary Sciences, Göttingen, 37075, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, 37075, Germany.<br /><searchLink fieldCode="AU" term="%22Wegmann+S%22">Wegmann S</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, 10117, Germany.<br /><searchLink fieldCode="AU" term="%22Lashley+T%22">Lashley T</searchLink>; UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Polymenidou+M%22">Polymenidou M</searchLink>; University of Zurich, Zurich, 8006, Switzerland.<br /><searchLink fieldCode="AU" term="%22Edbauer+D%22">Edbauer D</searchLink>; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, 81377, Germany. dieter.edbauer@dzne.de.; Graduate School of Systemic Neurosciences (GSN), Planegg, 82152, Germany. dieter.edbauer@dzne.de.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany. dieter.edbauer@dzne.de.<br /><searchLink fieldCode="AU" term="%22Dormann+D%22">Dormann D</searchLink>; Johannes Gutenberg University (JGU), Institute of Molecular Physiology, Mainz, 55122, Germany. ddormann@uni-mainz.de.; Institute of Molecular Biology (IMB), Mainz, 55122, Germany. ddormann@uni-mainz.de.; Munich Cluster of Systems Neurology (SyNergy), Munich, 81377, Germany. ddormann@uni-mainz.de.
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