Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency.

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Title: Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency.
Authors: Tang P; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom., Zickuhr GM; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K., Dickson AL; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K., Harding CJ; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, L69 3BX Liverpool, U.K., Devi S; Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, L69 7ZB Liverpool, U.K., Lebl T; School of Chemistry and Biomedical Sciences Research Complex, University of St Andrews and EaStCHEM, North Haugh, St Andrews, Fife KY16 9ST, United Kingdom., Harrison DJ; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K.; NuCana Plc, Edinburgh, EH12 9DT, United Kingdom., da Silva RG; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom., Czekster CM; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom.
Source: ACS chemical biology [ACS Chem Biol] 2025 Nov 21; Vol. 20 (11), pp. 2547-2553. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1554-8937
DOI:10.1021/acschembio.5c00120