Long-term outcomes from pembrolizumab monotherapy in patients with advanced NSCLC, PD-L1 expression ≥ 50 %, and poor performance status: Transformer-based AI to characterize prognostic complexity.

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Title: Long-term outcomes from pembrolizumab monotherapy in patients with advanced NSCLC, PD-L1 expression ≥ 50 %, and poor performance status: Transformer-based AI to characterize prognostic complexity.
Authors: Cortellini A; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Roma, Italy; Department of Surgery and Cancer, Imperial College of London, Hammersmith Hospital Campus, Du Cane Road, London, UK. Electronic address: a.cortellini@policlinicocampus.it., Garbo E; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, the United States of America., La Cava G; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Roma, Italy., Citarella F; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Roma, Italy., Santo V; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Roma, Italy; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, the United States of America., Brunetti L; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Roma, Italy; Department of Surgery and Cancer, Imperial College of London, Hammersmith Hospital Campus, Du Cane Road, London, UK., Pinato DJ; Department of Surgery and Cancer, Imperial College of London, Hammersmith Hospital Campus, Du Cane Road, London, UK; Translational Medicine Department, University of Eastern Piedmont, AOU Maggiore della Carità Hospital, Novara, Italy., Naidoo J; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland; RCSI University of Health Sciences, Dublin, Ireland; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, the United States of America., Loza M; Department of Medicine, Stanford Cancer Institute, Division of Oncology, Stanford University, Sanford, CA, the United States of America., Genova C; Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Internal Medicine and Medical Specialties, University of Genoa, Italy., Gettinger S; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, the United States of America., Kim SY; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, the United States of America., Jayakrishnan R; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, the United States of America., Zarif TE; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, the United States of America., Russano M; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy., Pecci F; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, the United States of America., Di Federico A; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, the United States of America., Montrone M; Medical Thoracic Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy., Owen DH; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, the United States of America; Pelotonia Institute for Immuno-Oncology, OSUCCC - James, The Ohio State University, Columbus, OH 43210, the United States of America., Signorelli D; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy., Li M; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, the United States of America., Camerini A; Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Italy., Halmos B; Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, the United States of America., Vincenzi B; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Roma, Italy., Metro G; Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliero-Universitaria di Perugia, Perugia, Italy., Yendamuri S; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, the United States of America., Grossi F; Medical Oncology Division, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy., Josephides E; Medical Oncology, Guy's and St Thomas' Hospitals NHS Trust, London, UK., Tomasik B; Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland; Centre for Experimental Cardiooncology, Medical University of Gdansk, Gdansk, Poland., Giusti R; Medical Oncology Unit. Sant'Andrea Hospital of Rome, Italy., Bria E; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy; Ospedale Isola Tiberina - Gemelli Isola, Roma, Italy., Sebastian M; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Rost M; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Acker F; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany., Landi L; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy., Mazzoni F; Medical Oncology Unit, Careggi University Hospital, Florence, Italy., Morabito A; Thoracic Medical Oncology, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Leonetti A; Medical Oncology Unit, University Hospital of Parma, Parma, Italy., Cantini L; Fortrea Inc., Durham, NC, the United States of America., Mountzios G; 4th Department of Medical Oncology and Clinical Trials Unit, Henry Dunant Hospital Center, Athens, Greece., Kalvapudi S; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, the United States of America., O'Reilly D; Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland., Karapanagiotou E; Medical Oncology, Guy's and St Thomas' Hospitals NHS Trust, London, UK., Monnet I; Service de Pneumologie, Centre Hospitalier Intercommunal, Creteil, France., Baena J; Hospital Universitario, 12 De Octubre, Madrid, Spain., Macerelli M; Department of Oncology, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy., Majem M; Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain., Piedra A; Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain., Cortinovis DL; Division of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori di Monza/ Department of Clinical Medicine, University of Milano-Bicocca, Via GB Pergolesi 33, 20900 Monza, Italy., Tonini G; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Roma, Italy., Minuti G; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy., Mezquita L; Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain., Gorria T; Medical Oncology Department, Hospital Clinic of Barcelona, Barcelona, Spain., Beninato T; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Lo Russo G; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., PrelaJ A; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., De Giglio A; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Biello F; Translational Medicine Department, University of Eastern Piedmont, AOU Maggiore della Carità Hospital, Novara, Italy., Nana FA; Division of Pneumology, Cliniques Universitaires St-Luc, UCLouvain, 1200 Brussels, Belgium., Dingemans AC; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands., Aerts JG; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands., Ferrara R; Università Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Department of Medical Oncology, Milan, Italy., Abu Hejleh T; Department of Internal Medicine, Medical Oncology, King Hussein Cancer Center, Amman, Jordan; Department of Internal Medicine, Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa, Iowa City, the United States of America., Takada K; Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan., Naqash AR; Medical Oncology/TSET Phase 1 Program, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, the United States of America., Garassino MC; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, the United States of America., Wakelee HA; Department of Medicine, Stanford Cancer Institute, Division of Oncology, Stanford University, Sanford, CA, the United States of America., Nassar A; Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, the United States of America., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, the United States of America., Soda P; Research Unit of Artificial Intelligence and Computer Systems, Department of Engineering, Università Campus Bio-Medico di Roma, Roma, Italy; Department of Diagnostics and Intervention, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden., Caruso CM; Research Unit of Artificial Intelligence and Computer Systems, Department of Engineering, Università Campus Bio-Medico di Roma, Roma, Italy., Guarrasi V; Research Unit of Artificial Intelligence and Computer Systems, Department of Engineering, Università Campus Bio-Medico di Roma, Roma, Italy.
Source: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2025 Nov; Vol. 209, pp. 108799. Date of Electronic Publication: 2025 Oct 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8332 (Electronic) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-8332
DOI:10.1016/j.lungcan.2025.108799