Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance.

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Title: Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance.
Authors: Utz AR; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Ma L; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Hilovsky D; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Zimmer BM; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Allego E; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Fluharty J; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Narasimhan P; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Enders JR; Molecular Education, Technology and Research Innovation Center, North Carolina State University, USA., Grady G; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Milici M; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Liu P; Department of Biochemistry and Biophysics, University of North Carolina - Chapel Hill, USA., Liu X; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Barycki JJ; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Simpson MA; Department of Molecular and Structural Biochemistry, North Carolina State University, USA. Electronic address: msimpso3@ncsu.edu.
Source: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2025 Dec; Vol. 142, pp. 33-45. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9432592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-1802 (Electronic) Linking ISSN: 0945053X NLM ISO Abbreviation: Matrix Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1569-1802
DOI:10.1016/j.matbio.2025.10.004