Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration.

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Title: Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration.
Authors: Gamen E; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Price EL; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Pezzolla D; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., De Villiers C; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Gunadasa-Rohling M; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Lokman AB; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Cosma MA; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Sayers J; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Silva CR; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Salama R; NDM Research Building, University of Oxford, Oxford, United Kingdom., Mole DR; NDM Research Building, University of Oxford, Oxford, United Kingdom., Bishop T; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.; NDM Research Building, University of Oxford, Oxford, United Kingdom.; Ludwig institute for Cancer Research, University of Oxford, Oxford, United Kingdom., Pugh CW; Target Discovery Institute, University of Oxford, Oxford, United Kingdom., Choudhury RP; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Carr CA; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Vieira JM; School of Cardiovascular and Metabolic Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London, United Kingdom., Riley PR; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Source: ELife [Elife] 2025 Oct 22; Vol. 14. Date of Electronic Publication: 2025 Oct 22.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gamen+E%22">Gamen E</searchLink>; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Price+EL%22">Price EL</searchLink>; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pezzolla+D%22">Pezzolla D</searchLink>; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22De+Villiers+C%22">De Villiers C</searchLink>; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gunadasa-Rohling+M%22">Gunadasa-Rohling M</searchLink>; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lokman+AB%22">Lokman AB</searchLink>; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cosma+MA%22">Cosma MA</searchLink>; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sayers+J%22">Sayers J</searchLink>; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Silva+CR%22">Silva CR</searchLink>; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Salama+R%22">Salama R</searchLink>; NDM Research Building, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mole+DR%22">Mole DR</searchLink>; NDM Research Building, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bishop+T%22">Bishop T</searchLink>; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.; NDM Research Building, University of Oxford, Oxford, United Kingdom.; Ludwig institute for Cancer Research, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pugh+CW%22">Pugh CW</searchLink>; Target Discovery Institute, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Choudhury+RP%22">Choudhury RP</searchLink>; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Carr+CA%22">Carr CA</searchLink>; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vieira+JM%22">Vieira JM</searchLink>; School of Cardiovascular and Metabolic Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Riley+PR%22">Riley PR</searchLink>; Institute of Developmental and Regenerative Medicine (IDRM), Oxford, United Kingdom.; Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
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