Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2.
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| Title: | Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2. |
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| Authors: | Li X; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu Province, China.; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.; Department of Respiratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, 214000, Jiangsu Province, China.; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Wang J; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu Province, China.; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Li S; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu Province, China.; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Fang J; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu Province, China.; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Hao Y; Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu Province, China., Xu C; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang Province, China., Shu Y; Department of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi Province, China., Shu H; Department of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi Province, China., Chen J; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China.; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China., Lu N; School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu Province, China., Zhu X; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu Province, China. zhuxue@jsinm.org.; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China. zhuxue@jsinm.org., Wang K; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu Province, China. wangke@jsinm.org.; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China. wangke@jsinm.org., Wang X; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu Province, China. 081104125@fudan.edu.cn.; Department of Respiratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, 214000, Jiangsu Province, China. 081104125@fudan.edu.cn. |
| Source: | Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2025 Dec; Vol. 48 (6), pp. 1795-1808. Date of Electronic Publication: 2025 Oct 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-3436 (Electronic) Linking ISSN: 22113428 NLM ISO Abbreviation: Cell Oncol (Dordr) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2211-3436 |
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| DOI: | 10.1007/s13402-025-01107-z |
