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Comprehensive resistance profiling of chronic myeloid leukaemia associated ABL1 variants against five tyrosine kinase inhibitors using prime editing.

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Title: Comprehensive resistance profiling of chronic myeloid leukaemia associated ABL1 variants against five tyrosine kinase inhibitors using prime editing.
Authors: Jung Y; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea., Yu G; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea.; Graduate School of Medical Science, Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea., Oh HC; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea., Lee JH; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea., Jeon E; Graduate School of Medical Science, Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea., Bae J; Graduate School of Medical Science, Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea., Sim T; Graduate School of Medical Science, Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea.; Clinical Candidate Discovery & Development Institute, Yonsei University College of Medicine, Seoul, Republic of Korea., Kim HH; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.; Graduate School of Medical Science, Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.; Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea. hkim1@yuhs.ac.; Yonsei-IBS Institute, Yonsei University, Seoul, Republic of Korea. hkim1@yuhs.ac.; Woo Choo Lee Institute for Precision Drug Development, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.; Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.; Won-Sang Lee Institute for Hearing Loss, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Jul; Vol. 10 (7), pp. 1392-1409. Date of Electronic Publication: 2025 Oct 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2157-846X
DOI:10.1038/s41551-025-01531-4