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Association between hot spring residency and dry eye disease: a crossover gene-environment interaction (GxE) study in Taiwan.

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Title: Association between hot spring residency and dry eye disease: a crossover gene-environment interaction (GxE) study in Taiwan.
Authors: Wu HY; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Chang KJ; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan.; Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; Department of Medical Education, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan., Chiu W; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Wang CY; Department of Medical Education, Taichung Veterans General Hospital, No. 1650, Taiwan Boulevard Sect. 4, Taichung, 407219, Taiwan., Lin YC; Department of Statistics, Tamkang University, No. 151, Yingzhuan Rd., Tamsui District, New Taipei, 251301, Taiwan., Hsu YT; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA., Wen YC; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan.; Department of Occupational Medicine and Clinical Toxicology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; Institute of Environmental and Occupational Health Sciences, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Chiang PH; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; Department of Statistics, Tamkang University, No. 151, Yingzhuan Rd., Tamsui District, New Taipei, 251301, Taiwan.; Big Data Center, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan., Chen YH; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Dai HJ; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Lu CH; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Chen YC; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Tsai HY; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; Department of Statistics, Tamkang University, No. 151, Yingzhuan Rd., Tamsui District, New Taipei, 251301, Taiwan.; Big Data Center, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan., Chen YC; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan.; Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan.; Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan., Hsu CH; Department of Environmental Medicine, Women's Hospital, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, No. 866, Yuhangtang Rd., Hangzhou, 310058, China.; International School of Medicine, Hangzhou 310006 Institute of Genetics, Zhejiang University School of Medicine, Zhejiang University, No. 866, Yuhangtang Rd., Hangzhou, 310058, China., Chiou SH; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; Institute of Pharmacology, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Yang YP; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan.; Institute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan., Hsieh AR; Department of Statistics, National Taipei University, No151, University Rd., San Shia District, 23741, New Taipei City, Taiwan., Hsu CC; Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan. chihchienym@gmail.com.; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou District, Taipei, 112304, Taiwan. chihchienym@gmail.com.; Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, 11217, Taiwan. chihchienym@gmail.com.
Source: Human genomics [Hum Genomics] 2025 Oct 22; Vol. 19 (1), pp. 120. Date of Electronic Publication: 2025 Oct 22.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101202210 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-7364 (Electronic) Linking ISSN: 14739542 NLM ISO Abbreviation: Hum Genomics Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1479-7364
DOI:10.1186/s40246-025-00824-8