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Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes.

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Title: Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes.
Authors: DeMeo B; Cellarity Inc, Somerville, MA, USA., Nesbitt C; Cellarity Inc, Somerville, MA, USA., Miller SA; Cellarity Inc, Somerville, MA, USA., Burkhardt DB; Cellarity Inc, Somerville, MA, USA., Lipchina I; Cellarity Inc, Somerville, MA, USA., Fu D; Cellarity Inc, Somerville, MA, USA., Holderrieth P; Cellarity Inc, Somerville, MA, USA., Kim D; Cellarity Inc, Somerville, MA, USA., Kolchenko S; Cellarity Inc, Somerville, MA, USA., Szalata A; Computational Health Center, Institute of Computational Biology, Helmholtz-Munich, Neuherberg, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany., Gupta I; Cellarity Inc, Somerville, MA, USA., Kerr C; Cellarity Inc, Somerville, MA, USA., Pfefer T; Cellarity Inc, Somerville, MA, USA., Rojas-Rodriguez R; Cellarity Inc, Somerville, MA, USA., Kuppassani S; Cellarity Inc, Somerville, MA, USA., Kruidenier L; Cellarity Inc, Somerville, MA, USA., Doshi PB; Cellarity Inc, Somerville, MA, USA., Zamanighomi M; Cellarity Inc, Somerville, MA, USA., Collins JJ; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Department of Biological Engineering, MIT Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Wyss Institute, Harvard University, Boston, MA, USA., Shalek AK; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Koch Institute for Integrative Cancer Research, MIT Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Theis FJ; Computational Health Center, Institute of Computational Biology, Helmholtz-Munich, Neuherberg, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany.; Helmholtz AI, Helmholtz-Munich, Neuherberg, Germany., Cortes M; Cellarity Inc, Somerville, MA, USA.
Source: Science (New York, N.Y.) [Science] 2025 Nov 27; Vol. 390 (6776), pp. eadi8577. Date of Electronic Publication: 2025 Nov 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes.
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  Data: <searchLink fieldCode="AU" term="%22DeMeo+B%22">DeMeo B</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nesbitt+C%22">Nesbitt C</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+SA%22">Miller SA</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Burkhardt+DB%22">Burkhardt DB</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lipchina+I%22">Lipchina I</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fu+D%22">Fu D</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Holderrieth+P%22">Holderrieth P</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kolchenko+S%22">Kolchenko S</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Szalata+A%22">Szalata A</searchLink>; Computational Health Center, Institute of Computational Biology, Helmholtz-Munich, Neuherberg, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Gupta+I%22">Gupta I</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kerr+C%22">Kerr C</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pfefer+T%22">Pfefer T</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rojas-Rodriguez+R%22">Rojas-Rodriguez R</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kuppassani+S%22">Kuppassani S</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kruidenier+L%22">Kruidenier L</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doshi+PB%22">Doshi PB</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zamanighomi+M%22">Zamanighomi M</searchLink>; Cellarity Inc, Somerville, MA, USA.<br /><searchLink fieldCode="AU" term="%22Collins+JJ%22">Collins JJ</searchLink>; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Department of Biological Engineering, MIT Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Wyss Institute, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shalek+AK%22">Shalek AK</searchLink>; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Koch Institute for Integrative Cancer Research, MIT Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Theis+FJ%22">Theis FJ</searchLink>; Computational Health Center, Institute of Computational Biology, Helmholtz-Munich, Neuherberg, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany.; Helmholtz AI, Helmholtz-Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cortes+M%22">Cortes M</searchLink>; Cellarity Inc, Somerville, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2025 Nov 27; Vol. 390 (6776), pp. eadi8577. <i>Date of Electronic Publication: </i>2025 Nov 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
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              Text: 2025 Nov 27
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