The TEMP-PREVENT trial: a study protocol for a randomized, double-blind, placebo-controlled clinical trial of etidronate for treatment in young adult patients with pseudoxanthoma elasticum.

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Title: The TEMP-PREVENT trial: a study protocol for a randomized, double-blind, placebo-controlled clinical trial of etidronate for treatment in young adult patients with pseudoxanthoma elasticum.
Authors: Harmsen IM; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands., Haverkamp M; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands., van den Beukel TC; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kok M; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Jong PA; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Valen E; Department of Neuropsychology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Leeuwen R; Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Norel JO; Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Spiering W; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands. W.Spiering@umcutrecht.nl.
Source: Trials [Trials] 2025 Oct 23; Vol. 26 (1), pp. 431. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1745-6215
DOI:10.1186/s13063-025-09064-6