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The TEMP-PREVENT trial: a study protocol for a randomized, double-blind, placebo-controlled clinical trial of etidronate for treatment in young adult patients with pseudoxanthoma elasticum.

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Title: The TEMP-PREVENT trial: a study protocol for a randomized, double-blind, placebo-controlled clinical trial of etidronate for treatment in young adult patients with pseudoxanthoma elasticum.
Authors: Harmsen IM; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands., Haverkamp M; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands., van den Beukel TC; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kok M; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Jong PA; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Valen E; Department of Neuropsychology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Leeuwen R; Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Norel JO; Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Spiering W; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands. W.Spiering@umcutrecht.nl.
Source: Trials [Trials] 2025 Oct 23; Vol. 26 (1), pp. 431. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Harmsen+IM%22">Harmsen IM</searchLink>; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Haverkamp+M%22">Haverkamp M</searchLink>; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Beukel+TC%22">van den Beukel TC</searchLink>; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kok+M%22">Kok M</searchLink>; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Jong+PA%22">de Jong PA</searchLink>; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Valen+E%22">van Valen E</searchLink>; Department of Neuropsychology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Leeuwen+R%22">van Leeuwen R</searchLink>; Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Norel+JO%22">Norel JO</searchLink>; Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Spiering+W%22">Spiering W</searchLink>; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, Utrecht, 3508 GA, the Netherlands. W.Spiering@umcutrecht.nl.
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  Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2025 Oct 23; Vol. 26 (1), pp. 431. <i>Date of Electronic Publication: </i>2025 Oct 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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              Text: 2025 Oct 23
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