Large transient assemblies of Apaf1 constitute the apoptosome in cells.

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Title: Large transient assemblies of Apaf1 constitute the apoptosome in cells.
Authors: Borgeaud AC; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.; MRC Laboratory of Molecular Biology, Cambridge, UK., Ganeva I; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.; MRC Laboratory of Molecular Biology, Cambridge, UK., Klein C; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland., Stooss A; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland., Ross-Kaschitza D; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland., Wu L; Institute of Pharmacology, University of Bern, Bern, Switzerland., Riley JS; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Institute of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Tait SWG; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Lemmin T; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland., Kaufmann T; Institute of Pharmacology, University of Bern, Bern, Switzerland., Kukulski W; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland. wanda.kukulski@unibe.ch.; MRC Laboratory of Molecular Biology, Cambridge, UK. wanda.kukulski@unibe.ch.
Source: Nature communications [Nat Commun] 2025 Oct 24; Vol. 16 (1), pp. 9429. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-64478-9